CARBOXY-PTIO Chemical Properties

Melting point:

141-143°C

storage temp. 

2-8°C

solubility 

H₂O: >20 mg/mL

form 

solid

color 

blue

Water Solubility 

Soluble in water. Also soluble in ethanol, methanol, DMSO or DMF.

Stability:

Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

CAS DataBase Reference

148819-94-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

2918999090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

CARBOXY-PTIO Usage And Synthesis

Description

A nitric oxide (NO) scavenger.? Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2–/NO3–.?? In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4

Chemical Properties

blue powder

Uses

A water soluble, stable organic free radical that reacts stoichiometrically with NO. Carboxy-PTIO converts NO to NO2 and does not dramatically affect other NO related metabolites. This scavenger allows for the specific investigation of the effect of NO.

Uses

Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.

Uses

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Definition

ChEBI: Potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide is a potassium salt having 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide as the counterion. It has a role as a radical scavenger and an apoptosis inhibitor. It is a potassium salt and an organic radical. It contains a carboxylato-PTIO.

General Description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide?(carboxy-PTIO) is mainly considered as a scavenger of nitric oxide?(NO).

Biological Activity

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N( ω )-nitroarginine or N-methylarginine.

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide?(NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

storage

+4°C

References

Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827 Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biochem. Biophys. Res. Commun., 202 923 Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; Int. J. Mol. Sci., 20 4327 Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; Eur. J. Pharmacol., 885 173497

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