Z-PHE-PHE-FLUOROMETHYLKETONE Chemical Properties

Boiling point:

707.5±60.0 °C(Predicted)

Density 

1.214±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO: 20mM

form 

solid

pka

11.07±0.46(Predicted)

color 

White to off-white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Z-PHE-PHE-FLUOROMETHYLKETONE Usage And Synthesis

Uses

Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L/B inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

Biological Activity

Cell permeable: yes', 'Primary Target
cathepsin L', 'Product does not compete with ATP.', 'Reversible: no

IC 50

Cathepsin B; cathepsin L

References

[1] Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21. DOI:10.1186/s13024-020-00369-5