N-(3,4-dichlorophenyl)-N-methylpropionamide Chemical Properties

Boiling point:

336.8±32.0 °C(Predicted)

Density 

1.279±0.06 g/cm3(Predicted)

pka

-1.39±0.50(Predicted)

N-(3,4-dichlorophenyl)-N-methylpropionamide Usage And Synthesis

Uses

ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2].

References

[1] Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11(3):eabm9843. DOI:10.1126/sciadv.abm9843
[2] McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12(4):e1230. DOI:10.1002/prp2.1230