DM1-SPP
DM1-SPP Basic information
- Product Name:
- DM1-SPP
- Synonyms:
-
- DM1-SPP
- SPP-DM1
- Maytansine, N2'-deacetyl-N2'-[3-[[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-4-oxobutyl]dithio]-1-oxopropyl]-
- CAS:
- 452072-20-7
- MF:
- C44H59ClN4O14S2
- MW:
- 967.54
- Mol File:
- 452072-20-7.mol
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DM1-SPP Chemical Properties
- Density
- 1.39±0.1 g/cm3(Predicted)
- pka
- 9.82±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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DM1-SPP Usage And Synthesis
Uses
SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].
IC 50
Maytansinoids
References
[1] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. DOI:10.1158/1535-7163.MCT-10-0644
DM1-SPPSupplier
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
BOC Sciences
- Tel
- +1-631-485-4226
- inquiry@bocsci.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
Guangzhou Junze Biotechnology Co., Ltd.
- Tel
- 17688489295