N,N'-DINITROSOPIPERAZINE
N,N'-DINITROSOPIPERAZINE Basic information
- Product Name:
- N,N'-DINITROSOPIPERAZINE
- Synonyms:
-
- N,N'-DINITROSOPIPERAZINE
- TIMTEC-BB SBB008187
- 1,4-dinitroso-piperazin
- Dinitrosopiperazin
- Dinitrosopiperazine
- Dnpz
- NSC 339
- nsc339
- CAS:
- 140-79-4
- MF:
- C4H8N4O2
- MW:
- 144.13
- EINECS:
- 205-434-6
- Product Categories:
-
- Heterocycles
- Mutagenesis Research Chemicals
- Mol File:
- 140-79-4.mol
N,N'-DINITROSOPIPERAZINE Chemical Properties
- Melting point:
- 208-210°C
- Boiling point:
- 262.72°C (rough estimate)
- Density
- 1.4165 (rough estimate)
- refractive index
- 1.8500 (estimate)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -4.82±0.70(Predicted)
- color
- White to Pale Yellow
- Water Solubility
- 5.765g/L(24 ºC)
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C4H8N4O2/c9-5-7-1-2-8(6-10)4-3-7/h1-4H2
- InChIKey
- WNSYEWGYAFFSSQ-UHFFFAOYSA-N
- SMILES
- N1(N=O)CCN(N=O)CC1
- CAS DataBase Reference
- 140-79-4
- EPA Substance Registry System
- Piperazine, 1,4-dinitroso- (140-79-4)
Safety Information
- Hazardous Substances Data
- 140-79-4(Hazardous Substances Data)
N,N'-DINITROSOPIPERAZINE Usage And Synthesis
Chemical Properties
Pale Yellow Solid
Uses
N,N'-Dinitrosopiperazine (DNP) induces nasopharyngeal carcinoma (NPC) and shows organ specificity to the nasopharyneal epithelium.
Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, subcutaneous, and intraperitoned routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS.
in vivo
N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice[1].
| Animal Model: | BABL/c nude mice injected with labeled 6-10B cell suspensions (1?×?104?cells) with or without DNP(40 mg/kg)[1] |
| Dosage: | 40 mg/kg |
| Administration: | Injected into the tail veins; 30 days |
| Result: | Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo. |
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N,N'-DINITROSOPIPERAZINE(140-79-4)Related Product Information
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- 1-AMINO PIPERAZINE
- 1-nitrosopiperazine
- N,N-DIETHYLHYDRAZINE
- 2-METHYL-1,4-DINITROSOPIPERAZINE
- 2,3,5,6-Tetramethyl-1,4-dinitrosopiperazine
- (2R,6R)-2,6-DIMETHYL-1,4-DINITROSOPIPERAZINE
- 2-NITRO-1,4-DINITROSOPIPERAZINE
- (2R,5S)-2,5-DIMETHYL-1,4-DINITROSOPIPERAZINE
- 2,3-DIMETHYL-1,4-DINITROSOPIPERAZINE
- 1,4-DINITROSOPIPERAZINE-2-CARBOXYLIC ACID
- (2R,6S)-2,6-DIMETHYL-1,4-DINITROSOPIPERAZINE
- 2,6-DIMETHYL-1,4-DINITROSOPIPERAZINE