(S)-3,4-DCPG Chemical Properties

Boiling point:

531.0±50.0 °C(Predicted)

Density 

1.634±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

solubility 

DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 10 mg/ml

pka

1.59±0.10(Predicted)

form 

Powder

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

InChI

InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

InChIKey

IJVMOGKBEVRBPP-ZETCQYMHSA-N

SMILES

C1(C(O)=O)=CC=C([C@H](N)C(O)=O)C=C1C(O)=O

(S)-3,4-DCPG Usage And Synthesis

Uses

(S)-3,4-DCPG is a potent and selective mGluR-8a agonist.

Biological Activity

Potent, selective mGlu 8a agonist (EC 50 = 31 nM). Displays > 100-fold selectivity over mGlu 1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo . Also potent anticonvulsant in mice in vivo .

storage

Desiccate at RT

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