3-FLUORO-2-IODOPYRIDINE Chemical Properties

Boiling point:

203.1±20.0 °C(Predicted)

Density 

2.046±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

-0.58±0.10(Predicted)

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

146141-04-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

3-FLUORO-2-IODOPYRIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-fluoro-2-iodopyridine from 2-chloro-3-fluoropyridine: To a solution of 2-chloro-3-fluoropyridine (400 mg, 3 mmol) in dioxane (6 mL, 0.5 M) was added chlorotrimethylsilane (652 mg, 6 mmol) and sodium iodide (2.20 g, 15 mmol) in one go. The reaction mixture was stirred at 80 °C overnight. After completion of the reaction, the reaction mixture was concentrated to give 660 mg of 3-fluoro-2-iodopyridine (yield: 98%), the product was a yellow oil, which was directly used in the next reaction without further purification.

References

[1] Patent: WO2005/123703, 2005, A2. Location in patent: Page/Page column 223

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