5-Fluoro-2-iodopyridine Chemical Properties

Boiling point:

197℃

Density 

2.046

Flash point:

73℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-0.58±0.10(Predicted)

color 

yellow to off-white solid

Safety Information

HS Code 

2933399990

5-Fluoro-2-iodopyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-fluoro-2-iodopyridine from 2-bromo-5-fluoropyridine: under nitrogen protection, Cu2O (7.2 mg, 10 mol%), L-proline (11.5 mg, 20 mol%), 2-bromo-5-fluoropyridine (0.50 mmol), potassium iodide (KI, 249 mg, 0.75 mmol) and ethanol (EtOH, 1.5 mL). After sealing the Schlenk tube with a PTFE valve, the reaction mixture was stirred at 110 °C. The reaction process was monitored by gas chromatography (GC) analysis. Upon completion of the reaction, the yield was determined by GC using an appropriate internal standard (e.g., chlorobenzene or 1-chloro-4-methylbenzene) for highly volatile products; or the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether/ethyl acetate = 10/1) to give the target product 5-fluoro-2-iodopyridine.

References

[1] Catalysis Today, 2016, vol. 274, p. 129 - 132

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