METHYL 2-PYRIDYLACETATE Chemical Properties

Boiling point:

103 °C/0.5 mmHg (lit.)

Density 

1.119 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.506(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

pka

4.35±0.12(Predicted)

color 

Light yellow to Amber to Dark green

InChIKey

ORAKNQSHWMHCEY-UHFFFAOYSA-N

CAS DataBase Reference

1658-42-0

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

METHYL 2-PYRIDYLACETATE Usage And Synthesis

Chemical Properties

Clear yellow liquid

Synthesis

The general procedure for the synthesis of methyl 2-pyridylacetate from methanol and 2-pyridylacetic acid hydrochloride was as follows: the target compound was prepared by referring to literature methods. 2.00 g of 2-pyridine acetic acid hydrochloride (11.5 mmol, 1.00 eq.) was added to a round-bottom flask with 14 mL of methanol. The reaction system was cooled to 0 °C and 2.90 mL of trimethylchlorosilane (23.0 mmol, 2.00 eq.) was slowly added dropwise. After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residual solid was neutralized by slowly adding 40 mL of saturated aqueous sodium bicarbonate solution to the residual solid. Subsequently, the aqueous phase was extracted with dichloromethane (4 x 40 mL), and the organic phase was combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the crude product methyl 2-pyridylacetate (1.73 g, 11.47 mmol, quantitative yield) as a clear oil. The structure of the product was confirmed by comparing the spectral data of the compound with data reported in the literature.

References

[1] Tetrahedron, 2011, vol. 67, # 24, p. 4435 - 4441
[2] Patent: WO2017/87667, 2017, A1. Location in patent: Paragraph 0069
[3] Journal of the American Chemical Society, 2015, vol. 137, # 32, p. 10246 - 10253
[4] Journal of Organic Chemistry, 2001, vol. 66, # 20, p. 6595 - 6603

METHYL 2-PYRIDYLACETATE(1658-42-0)Related Product Information

• 2,6-Pyridinedicarbonitrile
• pyridine-3-sulfonyl chloride
• PYRIDINE-2,4-DICARBONITRILE
• METHYL 2-PYRIDYLACETATE
• Ethyl 2-pyridylacetate
• METHYL 4-PYRIDYLACETATE
• 2-Pyridylacetic acid
• DIETHYL 2-(8-HYDROXYQUINOLIN-2-YL)MALONATE
• DIMETHYL 2-(3-NITRO-2-PYRIDYL)MALONATE
• 2-(2-ETHOXY-2-OXOETHYL)NICOTINIC ACID
• DIETHYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]MALONATE
• METHYL 4-PYRIDYLACETATE HYDROCHLORIDE
• 4-(4-CHLOROPHENYL)-3-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-[(4-NITROPHENYL)METHYLENE]-2(5H)-FURANONE
• DIETHYL 2-[5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL]MALONATE
• 2-(4-CHLOROPHENYL)-2-OXOETHYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PROPANOATE
• BENZYL 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PROPANOATE
• RARECHEM AK ML 0005
• 4-(4-CHLOROPHENYL)-3-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-[(2,4-DICHLOROPHENYL)METHYLENE]-2(5H)-FURANONE