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Pyridine derivatives

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The important pyridine derivatives include niacin, nicotinamide, isonicotinoylhydrazine, nicotine, strychnine, and vitamin B6.

Vitamin B6 is a class of tetrasubstituted pyridine derivatives with coenzyme function, used clinically for the treatment of vomiting of pregnancy, radioactive vomiting, isoniazid poisoning, seborrheic dermatitis and pellagra, etc.

Pyridine is a kind of colorless or slightly yellow liquid with an alkalescence and special odor, naturally present in coal tar, shale oil, coal gas and petroleum. Miscible with water, alcohols, ethers, petroleum ether, oils, benzene, chloroform and most of other organic solvents, pyridine is an important chemical raw materials and solvents.

Similar to benzene with the same electronic structure pyridine has an almost hexagonal structure. The electron density of 2, 4, 6 sites is lower than that of 3, 5 sites due to the electronic absorption of nitrogen atoms in the ring. Therefore, in an acidic medium, electrophilic substitution reactions occur in the 3,5 positions and nucleophilic reactions such as amination, alkylation, arylation, acylation occur on the 2,4,6 position. Pyridine is a weak tertiary amine that can generate water-insoluble salts with various acids such as picric acid and perchloric acid in an ethanol solution; and pyridine hydrochloride ( C5H5N • HCl) can be generated by hydrochloric acid with pyridine due to its alkalescence. Piperidine can be generated from the hydrogenation of pyridine under the catalysis of nickel at 200 ℃ and 15 ~ 30MPa, or from the electrolysis reduction. It's relatively easier to be reduced but more difficult to be oxidized than benzene. But it can be oxidized by hydrogen peroxide or peroxy acids to form pyridine N-oxide, which is an important pyridine derivative.  Pyridine N-oxide can’t form a positively charged pyridinium cation after the oxidation of nitrogen atoms, which is therefore in favor of electrophilic substitution reaction of aryl group. Electrophilic substitution reactions of pyridine such as pyridine nitration, sulfonation and halogenation are difficult. But 3,5-dichloro-pyridine, or 3,4.5- trichloro pyridine can be obtained at more than 200 ℃ through halogenation which is slightly easier than the former two. Pyridine can form crystalline coordination compounds with various metal ions.

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Structure:
Chemical Name:
1-Hexadecylpyridinium bromide
CAS:
140-72-7
MF:
C21H38BrN
Structure:
Chemical Name:
4-(Trifluoromethyl)nicotinic acid
CAS:
158063-66-2
MF:
C7H4F3NO2
Structure:
Chemical Name:
Pyridine hydrochloride
CAS:
628-13-7
MF:
C5H6ClN
Structure:
Chemical Name:
2-Hydroxynicotinic acid
CAS:
609-71-2
MF:
C6H5NO3
Structure:
Chemical Name:
4,4'-DIBROMO-2,2'-BIPYRIDINE
CAS:
18511-71-2
MF:
C10H6Br2N2
Structure:
Chemical Name:
3-Bromo-5-methoxypyridine
CAS:
50720-12-2
MF:
C6H6BrNO
Structure:
Chemical Name:
2-Bromo-6-methoxypyridine
CAS:
40473-07-2
MF:
C6H6BrNO
Structure:
Chemical Name:
Methyl 2-aminopyridine-4-carboxylate
CAS:
6937-03-7
MF:
C7H8N2O2
Structure:
Chemical Name:
2,6-Pyridinedicarboxylic acid
CAS:
499-83-2
MF:
C7H5NO4
Structure:
Chemical Name:
Isonicotinic acid
CAS:
55-22-1
MF:
C6H5NO2
Structure:
Chemical Name:
(2-Chloro-3-pyridinyl)methanol
CAS:
42330-59-6
MF:
C6H6ClNO
Structure:
Chemical Name:
4-Acetylpyridine
CAS:
1122-54-9
MF:
C7H7NO
Structure:
Chemical Name:
3,5-Pyridinedicarboxylic acid
CAS:
499-81-0
MF:
C7H5NO4
Structure:
Chemical Name:
5-Bromopyridine-2-carboxylic acid
CAS:
30766-11-1
MF:
C6H4BrNO2
Structure:
Chemical Name:
2-Methoxy-5-pyridineboronic acid
CAS:
163105-89-3
MF:
C6H8BNO3
Structure:
Chemical Name:
2-Amino-3-pyridinecarboxaldehyde
CAS:
7521-41-7
MF:
C6H6N2O
Structure:
Chemical Name:
6-Fluoronicotinic acid
CAS:
403-45-2
MF:
C6H4FNO2
Structure:
Chemical Name:
3-Pyridylacetic acid hydrochloride
CAS:
6419-36-9
MF:
C7H8ClNO2
Structure:
Chemical Name:
Nipecotic acid
CAS:
498-95-3
MF:
C6H11NO2
Structure:
Chemical Name:
N-Boc-3-pyrrolidinone
CAS:
101385-93-7
MF:
C9H15NO3
Structure:
Chemical Name:
2-Bromopyridine-4-carboxylic acid
CAS:
66572-56-3
MF:
C6H4BrNO2
Structure:
Chemical Name:
2,6-Dichloro-5-fluoronicotinic acid
CAS:
82671-06-5
MF:
C6H2Cl2FNO2
Structure:
Chemical Name:
2-(Hydroxymethyl)pyridine
CAS:
586-98-1
MF:
C6H7NO
Structure:
Chemical Name:
2-Methoxypyridine
CAS:
1628-89-3
MF:
C6H7NO
Structure:
Chemical Name:
6-(Trifluoromethyl)nicotinic acid
CAS:
231291-22-8
MF:
C7H4F3NO2
Structure:
Chemical Name:
4,4'-Dimethyl-2,2'-bipyridyl
CAS:
1134-35-6
MF:
C12H12N2
Structure:
Chemical Name:
5-Chloro-7-azaindole
CAS:
866546-07-8
MF:
C7H5ClN2
Structure:
Chemical Name:
4-Chloronicotinic acid
CAS:
10177-29-4
MF:
C6H4ClNO2
Structure:
Chemical Name:
2-Chloro-3-pyridinecarboxaldehyde
CAS:
36404-88-3
MF:
C6H4ClNO
Structure:
Chemical Name:
3-Bromoisonicotinic acid
CAS:
13959-02-9
MF:
C6H4BrNO2
Structure:
Chemical Name:
2-Chloro-4-pyridinecarboxylic acid
CAS:
6313-54-8
MF:
C6H4ClNO2
Structure:
Chemical Name:
2,5-Dichloroisonicotinic acid
CAS:
88912-26-9
MF:
C6H3Cl2NO2
Structure:
Chemical Name:
Pyridinium chlorochromate
CAS:
26299-14-9
MF:
C5H6ClCrNO3
Structure:
Chemical Name:
2-Fluoronicotinic acid
CAS:
393-55-5
MF:
C6H4FNO2
Structure:
Chemical Name:
6-Bromopicolinic acid
CAS:
21190-87-4
MF:
C6H4BrNO2
Structure:
Chemical Name:
1-Methylpiperidin-4-amine
CAS:
41838-46-4
MF:
C6H14N2
Structure:
Chemical Name:
2-Hydroxy-5-pyridinecarboxylic acid
CAS:
5006-66-6
MF:
C6H5NO3
Structure:
Chemical Name:
2,2'-Bipyridine-4,4'-dicarboxylic acid
CAS:
6813-38-3
MF:
C12H8N2O4
Structure:
Chemical Name:
5,6-Dichloronicotinic acid
CAS:
41667-95-2
MF:
C6H3Cl2NO2
Structure:
Chemical Name:
2-Bromopyridine-5-carbaldehyde
CAS:
149806-06-4
MF:
C6H4BrNO
Structure:
Chemical Name:
5-Fluoronicotinic acid
CAS:
402-66-4
MF:
C6H4FNO2
Structure:
Chemical Name:
2-Chloro-6-methoxypyridine
CAS:
17228-64-7
MF:
C6H6ClNO
Structure:
Chemical Name:
2,5-PYRIDINEDICARBOXYLIC ACID
CAS:
100-26-5
MF:
C7H5NO4
Structure:
Chemical Name:
N-Methyl-4-chloropyridine-2-carboxamide
CAS:
220000-87-3
MF:
C7H7ClN2O
Structure:
Chemical Name:
2,6-Pyridinedimethanol
CAS:
1195-59-1
MF:
C7H9NO2
Structure:
Chemical Name:
Ethyl picolinate
CAS:
2524-52-9
MF:
C8H9NO2
Structure:
Chemical Name:
1,8-Diazabicyclo[5.4.0]undec-7-ene
CAS:
6674-22-2
MF:
C9H16N2
Structure:
Chemical Name:
Methyl 6-aminonicotinate
CAS:
36052-24-1
MF:
C7H8N2O2
Structure:
Chemical Name:
Cyclopenta[b]pyridine
CAS:
533-37-9
MF:
C8H9N
Structure:
Chemical Name:
5-Bromo-7-azaindole
CAS:
183208-35-7
MF:
C7H5BrN2
Structure:
Chemical Name:
3,4-Pyridinedicarboxylic acid
CAS:
490-11-9
MF:
C7H5NO4
Structure:
Chemical Name:
4-Chloropyridine-2-carboxylic acid
CAS:
5470-22-4
MF:
C6H4ClNO2
Structure:
Chemical Name:
5-Hydroxynicotinic acid
CAS:
27828-71-3
MF:
C6H5NO3
Structure:
Chemical Name:
5-Bromo-2-methoxypyridine
CAS:
13472-85-0
MF:
C6H6BrNO
Structure:
Chemical Name:
6-Methylpyridine-2-carbonitrile
CAS:
1620-75-3
MF:
C7H6N2
Structure:
Chemical Name:
3-BROMOPYRIDINE-2-CARBOXYLIC ACID
CAS:
30683-23-9
MF:
C6H4BrNO2
Structure:
Chemical Name:
PYRIDINE-2-CARBOXAMIDE
CAS:
1452-77-3
MF:
C6H6N2O
Structure:
Chemical Name:
2-Vinylpyridine
CAS:
100-69-6
MF:
C7H7N
Structure:
Chemical Name:
4-IODO-2-METHOXYPYRIDINE
CAS:
98197-72-9
MF:
C6H6INO
Structure:
Chemical Name:
2-Chloro-6-trifluoromethylnicotinic acid
CAS:
280566-45-2
MF:
C7H3ClF3NO2
Structure:
Chemical Name:
2-Methoxynicotinic acid
CAS:
16498-81-0
MF:
C7H7NO3
Structure:
Chemical Name:
N-Methylpyrrole-2-carboxylic acid
CAS:
6973-60-0
MF:
C6H7NO2
Structure:
Chemical Name:
2-Amino-6-methoxypyridine
CAS:
17920-35-3
MF:
C6H8N2O
Structure:
Chemical Name:
IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
CAS:
133427-08-4
MF:
C8H6N2O2
Structure:
Chemical Name:
6-Methoxynicotinic acid
CAS:
66572-55-2
MF:
C7H7NO3
Structure:
Chemical Name:
Methyl 2-amino-5-bromonicotinate
CAS:
50735-34-7
MF:
C7H7BrN2O2
Structure:
Chemical Name:
Methyl 2-chloro-6-methylpyridine-4-carboxylate
CAS:
3998-90-1
MF:
C8H8ClNO2
Structure:
Chemical Name:
2-Bromo-5-(trifluoromethyl)pyridine
CAS:
50488-42-1
MF:
C6H3BrF3N
Structure:
Chemical Name:
6-Bromonicotinic acid
CAS:
6311-35-9
MF:
C6H4BrNO2
Structure:
Chemical Name:
1-Acetyl-4-piperidinecarboxylic acid
CAS:
25503-90-6
MF:
C8H13NO3
Structure:
Chemical Name:
2-Picolinic acid
CAS:
98-98-6
MF:
C6H5NO2
Structure:
Chemical Name:
2-Fluoroisonicotinic acid
CAS:
402-65-3
MF:
C6H4FNO2
Structure:
Chemical Name:
4-Pyridylcarbinol
CAS:
586-95-8
MF:
C6H7NO
Structure:
Chemical Name:
2-(Trifluoromethyl)nicotinic acid
CAS:
131747-43-8
MF:
C7H4F3NO2
Structure:
Chemical Name:
5-Pyrimidinylboronic acid
CAS:
109299-78-7
MF:
C4H5BN2O2
Structure:
Chemical Name:
Isonicotinamide
CAS:
1453-82-3
MF:
C6H6N2O
Structure:
Chemical Name:
5-Bromopyridine-2-carbaldehyde
CAS:
31181-90-5
MF:
C6H4BrNO
Structure:
Chemical Name:
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
CAS:
55052-27-2
MF:
C7H5ClN2
Structure:
Chemical Name:
4-Methoxypyridine
CAS:
620-08-6
MF:
C6H7NO
Structure:
Chemical Name:
2-Methoxy-5-nitropyridine
CAS:
5446-92-4
MF:
C6H6N2O3
Structure:
Chemical Name:
4-Methoxypyridine N-oxide
CAS:
1122-96-9
MF:
C6H7NO2
Structure:
Chemical Name:
1-(4-Pyridyl)piperazine
CAS:
1008-91-9
MF:
C9H13N3
Structure:
Chemical Name:
4-Amino-2-methoxypyridine
CAS:
20265-39-8
MF:
C6H8N2O
Structure:
Chemical Name:
3-Pyridylboronic acid
CAS:
1692-25-7
MF:
C5H6BNO2
Structure:
Chemical Name:
DIMETHYL 2,6-PYRIDINEDICARBOXYLATE
CAS:
5453-67-8
MF:
C9H9NO4
Structure:
Chemical Name:
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
CAS:
75806-84-7
MF:
C6H2BrClF3N
Structure:
Chemical Name:
3-Chloropyridine-2-carboxylic acid
CAS:
57266-69-0
MF:
C6H4ClNO2
Structure:
Chemical Name:
3-Iodo-2-methoxypyridine
CAS:
112197-15-6
MF:
C6H6INO
Structure:
Chemical Name:
4-N-BOC-Aminopiperidine
CAS:
73874-95-0
MF:
C10H20N2O2
Structure:
Chemical Name:
5-Bromonicotinonitrile
CAS:
35590-37-5
MF:
C6H3BrN2
Structure:
Chemical Name:
4-Phenylpiperidine
CAS:
771-99-3
MF:
C11H15N
Structure:
Chemical Name:
2-Bromonicotinic acid
CAS:
35905-85-2
MF:
C6H4BrNO2
Structure:
Chemical Name:
Pyridine hydrofluoride
CAS:
32001-55-1
MF:
C5H6FN
Structure:
Chemical Name:
5-Amino-2-methoxypyridine
CAS:
6628-77-9
MF:
C6H8N2O
Structure:
Chemical Name:
2-Pyridylacetonitrile
CAS:
2739-97-1
MF:
C7H6N2
Structure:
Chemical Name:
5-Chloro-6-hydroxy-3-pyridinecarboxylic acid
CAS:
54127-63-8
MF:
C6H4ClNO3
Structure:
Chemical Name:
2,3-DIBROMO-5-METHYLPYRIDINE
CAS:
29232-39-1
MF:
C6H5Br2N
Structure:
Chemical Name:
2-Chloronicotinamide
CAS:
10366-35-5
MF:
C6H5ClN2O
Structure:
Chemical Name:
Methyl 6-methylnicotinate
CAS:
5470-70-2
MF:
C8H9NO2
Structure:
Chemical Name:
METHYL 2-CHLOROISONICOTINATE
CAS:
58481-11-1
MF:
C7H6ClNO2