2-Methoxypyridine Chemical Properties

Boiling point:

142 °C (lit.)

Density 

1.038 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.503(lit.)

FEMA 

4639 | 2-METHOXYPYRIDINE

Flash point:

90 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

pka

3.28(at 20℃)

color 

Clear colorless to slightly yellow

Odor

at 0.10?%?in?propylene glycol. green fermented tea

Water Solubility 

INSOLUBLE

JECFA Number

2156

BRN 

108189

InChIKey

IWTFOFMTUOBLHG-UHFFFAOYSA-N

LogP

1.32

CAS DataBase Reference

1628-89-3(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2-methoxy-(1628-89-3)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/37/38

Safety Statements 

26-36-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:2-Methoxypyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Methoxypyridine Usage And Synthesis

Synthesis

CsSO4F may be used to fluorinate pyridine directly, but the reaction is very sensitive to the solvents employed. When solvents such as pentane and diethyl ether were used, 2-fluoropyridine was the major product, but use of nucleophilic solvents, such as methanol gave 2-methoxypyridine.

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors.

2-Methoxypyridine(1628-89-3)Related Product Information

• 2,6-Dimethoxypyridine
• 2-Methoxy-3-nitropyridine
• 6-Chloro-2-methoxypyridine
• 2-PHENOXYNICOTINONITRILE
• 3-AMINO-2,6-DIMETHOXYPYRIDINE MONOHYDROCHLORIDE
• 2-Methoxypyridine
• 2-PHENOXYNICOTINIC ACID
• 2-ALLYLOXYPYRIDINE
• 2-N-BUTOXYPYRIDINE
• 2-CHLORO-6-ETHOXYPYRIDINE
• 2-Ethoxypyridine
• 2-Methoxy-5-nitropyridine
• Pyridine,3,4-dimethoxy-(9CI)
• 5-FLUORO-2-METHOXYPYRIDINE
• 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID
• 2-(2-FORMYL-1H-PYRROL-1-YL)-4-METHOXYNICOTINONITRILE
• 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE
• 6-methoxypyridine-2,3-diamine dihydrochloride