2,6-Dimethoxypyridine Chemical Properties

Boiling point:

178-180 °C (lit.)

Density 

1.053 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.503(lit.)

Flash point:

143 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

1.57±0.10(Predicted)

Specific Gravity

1.053

color 

Colorless to Almost colorless

BRN 

1525332

InChI

InChI=1S/C7H9NO2/c1-9-6-4-3-5-7(8-6)10-2/h3-5H,1-2H3

InChIKey

IBTGEEMBZJBBSH-UHFFFAOYSA-N

SMILES

C1(OC)=NC(OC)=CC=C1

CAS DataBase Reference

6231-18-1(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2,6-dimethoxy-(6231-18-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38-20/21/22

Safety Statements 

26-39-36/37/39-36

RIDADR 

1993

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,6-Dimethoxypyridine Usage And Synthesis

Uses

2,6-Dimethoxypyridine is widely used in drug molecules, such as enzyme inhibitors/agonists, anti-HIV drugs, antibacterial drugs, and anesthetics.

Chemical Properties

clear colorless to light yellow liquid

Synthesis

(1) In a 500 mL three-necked flask, 29.6 g (0.2 mol) of 2,6-dichloropyridine, 16 g (0.4 mol) of sodium hydroxide solid, and 200 mL of methanol were added sequentially. A reflux condensing unit was installed, magnetic stirring was turned on and heated to reflux. After maintaining the reflux reaction for 8 hours, the heating was stopped. Most of the methanol solvent was evaporated by rotary evaporator under reduced pressure. After the reaction solution was cooled to room temperature, it was diluted with 100 mL of water. Extraction and separation were carried out with dichloromethane (100 mL×1), and the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the dichloromethane was removed by spin distillation under reduced pressure to obtain the crude 2,6-dimethoxypyridine. Finally, the target fractions were collected by purification via decompression distillation to obtain the colorless and transparent liquid product 2,6-dimethoxypyridine in 94% yield.

References

[1] Patent: CN106905229, 2017, A. Location in patent: Paragraph 0028; 0029

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