IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Chemical Properties

Density 

1.41

storage temp. 

Sealed in dry,Room Temperature

pka

-0.61±0.41(Predicted)

form 

solid

color 

White

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-43

Safety Statements 

36/37

HS Code 

2933399990

IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of imidazo[1,2-a]pyridine-8-carboxylic acid from 2-aminonicotinic acid and 2-bromo-1,1-dimethoxyethane: To a suspension of 2-aminonicotinic acid (0.69 g, 5.00 mmol) in acetonitrile (20 mL) was added 2-bromo-1,1-dimethoxyethane (0.59 mL, 5.00 mmol). The resulting mixture was heated to 150 °C in a microwave reactor and kept for 2 hours. After completion of the reaction, the precipitate was collected by filtration and washed sequentially with acetonitrile and hexane to afford imidazo[1,2-a]pyridine-8-carboxylic acid (0.924 g) as a gray solid.

References

[1] Patent: WO2009/23253, 2009, A2. Location in patent: Page/Page column 52
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873

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