IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

232-234℃

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-4.33±0.41(Predicted)

form 

Powder

color 

White to off-white

CAS DataBase Reference

64951-08-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36-22

Safety Statements 

26-36/37/39-22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29332900

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White to off-white solid

Synthesis

Step 2: Synthesis of imidazo[1,2-a]pyridine-2-carboxylic acid Sodium hydroxide (85 mg, 2.1 mmol) was added to a stirred solution of ethyl imidazo[1,2-a]pyridine-2-carboxylate (135 mg, 0.7 mmol) in ethanol/water (1:1, 5.0 mL). The reaction mixture was heated at 60°C for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. Cold water was added, followed by acidification with 10% aqueous hydrochloric acid to pH < 7. The precipitated solid was collected by filtration and dried to afford imidazo[1,2-a]pyridine-2-carboxylic acid (110 mg, 73% yield).

References

[1] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 31
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 18, p. 3914 - 3929
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1572 - 1575

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID(64951-08-2)Related Product Information

• IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
• IMIDAZO[1,2-A]PYRIDIN-2-YLMETHANOL
• IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
• Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI),H-imidazo[1,2-a]pyridine-7-carboxylic acid
• H-imidazo[1,2-a]pyridine-6-carboxylic acid
• H-imidazo[1,2-a]pyridine-3-carboxylic acid
• Imidazo[1,2-a]pyridin-5-ylamine
• IMIDAZO[1,2-A]PYRAZINE-3-CARBALDEHYDE
• IMIDAZO[1,2-A]PYRIDIN-6-OL
• ETHYL IMIDAZO[1,2-A]PYRIDINE-7-CARBOXYLATE 98
• Dimethyl 4,5-imidazoledicarboxylate
• Imidazo[1,2-a]pyridine-6-boronic acid
• Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
• IMIDAZO[1,5-A]PYRIDINE-1-CARBOXYLIC ACID ETHYL ESTER
• ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
• METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
• Imidazo[1,2-a]pyridine-6-boronic acic pinacol ester