2-Bromo-6-methoxypyridine Chemical Properties

Boiling point:

206 °C (lit.)

Density 

1.53 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.559(lit.)

Flash point:

220 °F

storage temp. 

Inert atmosphere,Room Temperature

pka

-1.04±0.10(Predicted)

form 

Liquid

color 

Clear colorless to golden

InChI

InChI=1S/C6H6BrNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3

InChIKey

KMODISUYWZPVGV-UHFFFAOYSA-N

SMILES

C1(Br)=NC(OC)=CC=C1

CAS DataBase Reference

40473-07-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

2-Bromo-6-methoxypyridine Usage And Synthesis

Chemical Properties

Light yellow liquid

Uses

The commercial 2-Bromo-6-methoxypyridine could be used as a starting material to synthesize cyclopenta[b]pyridin-2,5-dione. The overall route consists of a first sequence of regioselective ortho lithiation and methoxycarbonylation followed by Heck vinylation, alkene reduction, cyclization, and decarboxylation[1].

References

[1] Robert, Nicolas , et al. "A convenient synthesis of cyclopenta[b]pyridin-2,5-dione as a non- glycosidic cardiotonic agent." ARKIVOC 2008.7(2008):92-100.

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