Pyridine hydrochloride Chemical Properties

Melting point:

145-147 °C(lit.)

Boiling point:

222-224 °C(lit.)

Density 

1.1182 (rough estimate)

refractive index 

1.5304 (estimate)

Flash point:

222-224°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

ethanol: soluble50mg/mL, clear, colorless to light yellow

form 

Crystals

color 

White to tan

Water Solubility 

85 g/100 mL

Sensitive 

Hygroscopic

BRN 

3615340

Stability:

Hygroscopic

InChIKey

AOJFQRQNPXYVLM-UHFFFAOYSA-N

CAS DataBase Reference

628-13-7(CAS DataBase Reference)

EPA Substance Registry System

Pyridine hydrochloride (628-13-7)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

UT4375000

F 

3-10

TSCA 

Yes

HS Code 

29333100

MSDS

• Language:English Provider:Pyridine hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Pyridine hydrochloride Usage And Synthesis

Chemical Properties

white to tan crystals

Uses

Pyridine Hydrochloride is the hydrochloride salt of pyridine, a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.

Preparation

Pyridine hydrochloride could be synthesized through the liquid-liquid synthesis method (pyridine and hydrochloric acid) and the gas-liquid synthesis method (pyridine and hydrogen chloride gas) respectively. The yield of the liquid-liquid synthesis method was 85% and the gas-liquid synthesis method was 92%.

Purification Methods

Crystallise the salt from CHCl3/EtOAc and wash it with Et2O. It is hygroscopic.[Beilstein 20 H 185, 20 I 57, 20 II 103, 20 III/IV 2230, 20/5 V 180.]

Pyridine hydrochloride(628-13-7)Related Product Information

• Pyridine hydrobromide
• Pyridine-4-boronic acid
• 3-HYDRAZINOPYRIDINE Dihydrochloride
• 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI)
• PYRIDIN-2-YL-METHANESULFONYL CHLORIDE
• Pyridine sulfur trioxide
• Pyridine
• 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
• 2-Pyridinecarboxaldehyde
• 2,6-Pyridinedicarbonitrile
• 4-Pyridinesulfonamide(6CI,9CI)
• 2,3,5,6-Tetraaminopyridine trihydrochloride
• Pyridine trifluoroacetate
• PYRIDINE-2-THIOAMIDE
• 2-Pyridinesulfonamide(6CI,7CI,9CI)
• dimethyl pyridine-3,5-dicarboxylate
• METHYL ISONICOTINATE
• Pyridine-N-oxide