dimethyl pyridine-3,5-dicarboxylate Chemical Properties

Melting point:

84-85 °C

Boiling point:

267.6±20.0 °C(Predicted)

Density 

1.231±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Dichloromethane, Methanol

form 

Solid

pka

1.16±0.20(Predicted)

color 

Pale Yellow

Safety Information

HS Code 

2933399990

dimethyl pyridine-3,5-dicarboxylate Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

Dimethyl 3,5-Pyridinedicarboxylate (cas# 4591-55-3) is a compound useful in organic synthesis.

Synthesis

The general procedure for the synthesis of methyl 3,5-pyridinedicarboxylate from methanol and 3,5-pyridinedicarboxylic acid is as follows: 3,5-pyridinedicarboxylic acid (5.00 g, 29.92 mmol) was dissolved in methanol (100 ml), concentrated sulfuric acid (2 ml) was added slowly as a catalyst, and the reaction mixture was stirred for 18 hrs under reflux conditions. After completion of the reaction, the solvent methanol was removed by distillation under reduced pressure. Subsequently, the reaction mixture was neutralized with aqueous sodium bicarbonate and separated by extraction with dichloromethane. The dichloromethane layer was collected and washed with saturated aqueous sodium chloride solution to remove residual water-soluble impurities. Eventually, the dichloromethane layer was concentrated by decompression to give the white solid product methyl 3,5-pyridinedicarboxylate (5.5 g, 94% yield).

References

[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 10, p. 933 - 938
[2] Patent: KR2018/9249, 2018, A. Location in patent: Paragraph 0250; 0251
[3] Angewandte Chemie - International Edition, 2004, vol. 43, # 30, p. 3914 - 3918
[4] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 9, p. 2397 - 2400
[5] Life Sciences, 2005, vol. 78, # 5, p. 495 - 505

dimethyl pyridine-3,5-dicarboxylate(4591-55-3)Related Product Information

• Pyridine hydrochloride
• 2,6-Pyridinedicarbonitrile
• 4-Pyridinesulfonamide(6CI,9CI)
• 2,3,5,6-Tetraaminopyridine trihydrochloride
• Pyridine trifluoroacetate
• PYRIDINE-2-THIOAMIDE
• 2-Pyridinesulfonamide(6CI,7CI,9CI)
• METHYL ISONICOTINATE
• Pyridine-N-oxide
• 2-Pyridinecarbaldehyde oxime
• PYRIDINE-2-SULFONYL FLUORIDE
• PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
• DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
• Diethyl pyridine-3,5-dicarboxylate
• dimethyl pyridine-3,5-dicarboxylate
• DIMETHYL 4-(4-METHOXYPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE
• Dehydronitrendipine
• OXIDIZED NIFEDIPINE