Sieber Linker
Sieber Linker Basic information
- Product Name:
- Sieber Linker
- Synonyms:
-
- SIEBER LINKER
- SALOR-INT L254835-1EA
- HF
- 6-HYDROXY-3-FLUORONE
- 3-HYDROXY-XANTHEN-9-ONE
- 3-HYDROXYXANTHONE
- 3-Hydroxy-9H-xanthen-9-one
- SIEBER LINKER,3-HYDROXY-XANTHEN-9-ONE
- CAS:
- 3722-51-8
- MF:
- C13H8O3
- MW:
- 212.2
- EINECS:
- 1312995-182-4
- Product Categories:
-
- Linkers for Solid Phase Synthesis
- Linkers for solid phase synthesis
- linker
- Mol File:
- 3722-51-8.mol
Sieber Linker Chemical Properties
- Melting point:
- 243 °C
- Boiling point:
- 403.9±24.0 °C(Predicted)
- Density
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 7.52±0.20(Predicted)
- form
- Solid
- color
- White to Orange to Green
- InChI
- InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
- InChIKey
- XCJHDJAODLKGLG-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
- CAS DataBase Reference
- 3722-51-8(CAS DataBase Reference)
Sieber Linker Usage And Synthesis
Chemical Properties
White to off-white or grey powder
Uses
Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.
Synthesis Reference(s)
Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6
Purification Methods
Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]
Sieber Linker Preparation Products And Raw materials
Raw materials
Sieber LinkerSupplier
- Tel
- 0512-69209928 18306209922
- cathyjia@highfine.com
- Tel
- 028-86293627 15228898511
- sales@yontinotech.com
- Tel
- +86-29-88665278 13379235092
- sales@vedachem.com
- Tel
- 13356310019 13356310019
- boyu2024@163.com
- Tel
- 021-021-64975436 18917636693
- 1377976036@qq.com
Sieber Linker(3722-51-8)Related Product Information
- Glycolic acid
- 4-Hydroxybenzoic acid
- 4-Hydroxybenzaldehyde
- Methylparaben
- Hydroxy silicone oil
- 4'-Hydroxyacetophenone
- CHLOROPHOSPHONAZO III
- Hydroxyapatite
- Camptothecin Series--10-hydroxycamptothecin
- Glycolonitrile
- mepixanox
- STERIGMATOCYSTIN
- Mangostin
- Mangiferin
- GENTISIN
- isomangiferin
- bellidifolin
- isogentisin