1,3-Dimethoxybenzene Chemical Properties

Melting point:

-52°C

Boiling point:

85-87 °C7 mm Hg(lit.)

Density 

1.055 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.524(lit.)

FEMA 

2385 | M-DIMETHOXYBENZENE

Flash point:

190 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Miscible with toluene.

form 

Liquid

color 

Clear colorless to slightly brown

Odor

at 1.00 % in dipropylene glycol. acid fruity nutmeg neroli

Odor Type

medicinal

Water Solubility 

1.216g/L(25 ºC)

JECFA Number

1249

BRN 

878582

Dielectric constant

4.5（23.0℃）

LogP

2.21

CAS DataBase Reference

151-10-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,3-dimethoxy-(151-10-0)

EPA Substance Registry System

m-Dimethoxybenzene (151-10-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25

RIDADR 

NA 1993 / PGIII

WGK Germany 

2

RTECS 

CZ6474000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29093090

Toxicity

mouse,LD50,intraperitoneal,900mg/kg (900mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ATAXIABEHAVIORAL: TREMOR,Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 185, 1957.

MSDS

• Language:English Provider:Resorcinol dimethyl ether
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,3-Dimethoxybenzene Usage And Synthesis

Description

1,3-Dimethoxybenzene, also known as dimethyl resorcinol or 3-methoxyanisole, belongs to the class of organic compounds known as dimethoxybenzenes. These organic aromatic compounds contain a monocyclic benzene moiety carrying two methoxy groups. 1,3-Dimethoxybenzene has been used in the synthesis of novel oxathiane spiroketal donors. It forms pi- and O-ylidic complexes with dichlorocarbene (CCl(2)).

Chemical Properties

m-Dimethoxybenzene has a very powerful sweet-earthy, intensely, nut-like aroma.

Occurrence

Reported found in Gruyere de Comte, blue cheeses, filberts and cognac

Uses

1,3-Dimethoxybenzene is used for the preparation of oxathiane spiroketal donors. It is also used for the formation of pi- and O-ylidic complexes with dichlorocarbene. Further, it acts as a flavoring agent.

Definition

ChEBI: 1,3-Dimethoxybenzene is a member of methoxybenzenes.

Production Methods

1,3-Dimethoxybenzene can be produced 1) by Methylation of Resorcinol in weak aqueous alkali with Dimethylsulfate. 2) from Methanol and Resorcinol with Potassium hydrosuIfate or Sodium naphthalene sulfonate as dehydrating agent.

Taste threshold values

Chemical, medicinal, spice, cooling root beer-like.

Synthesis Reference(s)

The Journal of Organic Chemistry, 55, p. 991, 1990 DOI: 10.1021/jo00290a033

General Description

1,3-Dimethoxybenzene can be used as a flavoring agent in the food industry. It is reported to be found in the volatiles of port wine and Roquefort cheese.

Purification Methods

Extract it with aqueous NaOH, and water, then dry it. Fractionally distil it from BaO or Na. [Beilstein 6 IV 5663.]

1,3-Dimethoxybenzene(151-10-0)Related Product Information

• Isophthalic acid
• ETHANE
• Dimethyldimethoxysilane
• Dimethyl sulfate
• Dimethyl carbonate
• Dimethyl fumarate
• Dimethyl ether
• Dibutyl phthalate
• Dacthal
• 1,2-Dimethoxyethane
• 1,1-Dimethoxyethane
• O-Phthalimide
• 2,3-Dimethoxybenzoic acid
• Resorcinol
• Dimethyl sulfoxide
• 2,3-Dimethoxybenzaldehyde
• N,N-Dimethylformamide
• 1,3-Dicyanobenzene