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DME

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DME Basic information

Product Name:
DME
Synonyms:
  • 1,2-dimethoxy-ethan
  • 1,2-Ethanediol dimethyl ether
  • DME
  • 1,2-DIMETHOXYETHANE, 99%1,2-DIMETHOXYETHANE, 99%1,2-DIMETHOXYETHANE, 99%
  • 1,2-Dimethoxyethane( 99.5%, HyDry, with molecular sieves, Water≤50 ppm (by K.F.))
  • 1,2-Dimethoxyethane(99%, HyDry, Water≤50 ppm (by K.F.))
  • 1,2-Dimethoxyethane Factory
  • 1,2-Dimethoxyethane, stab. with 0.01% BHT
CAS:
110-71-4
MF:
C4H10O2
MW:
90.12
EINECS:
203-794-9
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Mol File:
110-71-4.mol
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DME Chemical Properties

Melting point:
-69 °C
Boiling point:
85 °C(lit.)
Density 
0.867 g/mL at 25 °C(lit.)
vapor density 
3.1 (20 °C, vs air)
vapor pressure 
48 mm Hg ( 20 °C)
refractive index 
n20/D 1.379(lit.)
Flash point:
32 °F
storage temp. 
Store below +30°C.
solubility 
1000g/l soluble
form 
Liquid
color 
Clear
explosive limit
10.4%
Water Solubility 
Miscible
Sensitive 
Air Sensitive
λmax
λ: 220 nm Amax: 1.00
λ: 250 nm Amax: 0.20
λ: 300 nm Amax: 0.03
λ: 350-400 nm Amax: 0.01
Merck 
14,3224
BRN 
1209237
Stability:
Stable, but explosive peroxides may form on exposure to air. Test for the presence of peroxides before heating. Avoid heat, light, air. Highly flammable. Store under inert gas.
InChIKey
XTHFKEDIFFGKHM-UHFFFAOYSA-N
LogP
-0.21 at 25℃
CAS DataBase Reference
110-71-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethane, 1,2-dimethoxy-(110-71-4)
EPA Substance Registry System
Ethylene glycol dimethyl ether (110-71-4)
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Safety Information

Hazard Codes 
F,T
Risk Statements 
60-61-11-19-20-38
Safety Statements 
53-45
RIDADR 
UN 2252 3/PG 2
WGK Germany 
1
RTECS 
KI1451000
3-10-23
Autoignition Temperature
396 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29091900
Hazardous Substances Data
110-71-4(Hazardous Substances Data)

MSDS

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DME Usage And Synthesis

Synthesis

1,2-Dimethoxyethane is derived from the reaction of ethylene glycol monomethyl ether with sodium metal and methyl chloride. The ethylene glycol monomethyl ether and the metal sodium were refluxed together until the metal sodium was completely reacted, the temperature was lowered to 45° C., and methyl chloride was introduced. After the reaction is completed, fractional distillation is performed to collect fractions at 84-85.5°C to obtain 1,2-Dimethoxyethane.

Chemical Properties

Colorless liquid

Uses

Solvent commonly employed in organometallic reactions,1 particularly organolithium reactions.2 May also function as a ligand.3

Uses

Monoglyme is used in the electrolyte solutions for lithium batteries.

Uses

1,2-Dimethoxyethane is widely used as a solvent for electrolyte of lithium batteries, polysilicones, oligo- and polysaccharides. It plays an important role in Grignard reactions, Suzuki reactions and Stille couplings in organometallic chemistry and in pharmaceutical synthesis. It is a higher boiling point solvent and is used as an alternative to diethyl ether and tetrahydrofuran. It is used for the etching of synthetic polymers like polytetrafluoroethylene and other fluoropolymers with alkali metal dispersions.

Definition

ChEBI: A diether that is the 1,2-dimethyl ether of ethane-1,2-diol.

General Description

A liquid with a sharp odor. Less dense than water. Flash point 34°F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

When the solvent, 1,2-Dimethoxyethane, was poured into a funnel previously used to introduce the lithium aluminum hydride, a fire ignited the funnel, [MCA Case History 1182(1966)].

Hazard

Moderate fire risk.

Health Hazard

If ingested causes nausea, vomiting, cramps, weakness, coma.

Fire Hazard

Behavior in Fire: Containers may explode in fires.

Flammability and Explosibility

Highlyflammable

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Readdy forms an explosive peroxide. A very dangerous fire hazard when exposed to heat, flame, or oxidzers. Mixture with lithium tetrahydroaluminate may ignite orexplode if heated. When heated to decomposition it emits acrid smoke and fumes. See also GLYCOL ETHERS.

Purification Methods

Traces of water and acidic materials have been removed from it by refluxing with Na, K or CaH2, decanting and distilling from Na, K, CaH2 or LiAlH4. The reaction has been speeded up by using vigorous high-speed stirring with molten potassium. For virtually complete elimination of water, 1,2-dimethoxyethane has been dried with Na-K alloy until a characteristic blue colour is formed in the solvent at Dry-ice/cellosolve temperatures: the solvent is kept with the alloy until distilled for use [Ward J Am Chem Soc 83 1296 1961]. Alternatively, glyme, refluxed with benzophenone and Na-K, is dry enough if, on distillation, it gives a blue colour of the ketyl immediately on addition to benzophenone and sodium [Ayscough & Wilson J Chem Soc 5412 1963]. It has also been purified by distillation under N2 from sodium benzophenone ketyl (see above). [Beilstein 1 IV 2376.]

DMESupplier

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