Ethylene glycol diphenyl ether Chemical Properties

Melting point:

94-96 °C (lit.)

Boiling point:

185 °C / 12mmHg

Density 

1.0781 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5570 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

22mg/L at 25℃

BRN 

2052248

InChIKey

XCSGHNKDXGYELG-UHFFFAOYSA-N

LogP

3.81 at 25℃

CAS DataBase Reference

104-66-5(CAS DataBase Reference)

EPA Substance Registry System

2-Phenoxyethyl phenyl ether (104-66-5)

Safety Information

Risk Statements 

51/53

Safety Statements 

22-24/25-61-36-29/56

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

TSCA 

Yes

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethylene glycol diphenyl ether Usage And Synthesis

Chemical Properties

Off-white Crystals

Uses

1,2-Diphenoxyethane is a reagent that is used in the production and use of activatable delivery compounds containing drugs or a detectable moiety and singlet oxygen-labile linkers.

Preparation

The preparation of Ethylene glycol diphenyl ether is as follows:A three-necked flask was charged with 15.7 g of bromobenzene (100 mmol) and 47 ml of DMF, and stirred. 12.7 g of sodium carbonate (120 mmol, 1.2 eq.), 1.9 g of cuprous iodide (10 mmol, 0.1 eq.), 1.87 g of 2,2'-bipyridine (12 mmol, 0.1 eq.) and 7.4 g of ethylene glycol (120 mmol, 1.2 equivalent), the reaction mixture was stirred at 100 ° C overnight. After recovering DMF under reduced pressure, 100 ml of water and 100 ml of toluene were added, and the aqueous phase was extracted three times with 300 ml of toluene, and the organic layers were combined. Washed sequentially with 5% sodium carbonate. The organic phase was dried over anhydrous sodium sulfate, filtered, and then filtered and evaporated,The crude product was recrystallized from isopropanol and dried in vacuo to give 19.5 g of product, yield 91%, purity over 99%.

Application

Ethylene glycol diphenyl ether can be used as a new heat-sensitive material sensitizer and a potential polyolefin catalyst additive.

General Description

1,2-Diphenoxyethane is the intermediate formed during sonochemical oxidation of phenoxyacetic acid and chlorophenol.

Flammability and Explosibility

Non flammable

Ethylene glycol diphenyl ether(104-66-5)Related Product Information

• 2-Ethoxyethanol
• Ethylene glycol diethyl ether
• 1,2-Dimethoxyethane
• Ethylene Glycol Dibutyl Ether
• ETHYLENE GLYCOL DIBENZYL ETHER
• Rotenone
• DIBROMOBAPTA
• Fura 2-AM
• BAPTA
• 1,2-Bis(2,4,6-tribromophenoxy)ethane
• 1,2-Bis(2-Nitrophenoxy)ethane
• Bis(2,4,6-trichlorophenyl)ethanedioate
• OXALIC ACID DIPHENYL ESTER
• DIBENZO-15-CROWN-5
• BAPTA-AM
• 2-2-(2-Aminophenoxy)ethoxyaniline
• ETHANE
• Diphenyl ether