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Pyridine-4-boronic acid

Basic information Uses Safety Supplier Related

Pyridine-4-boronic acid Basic information

Product Name:
Pyridine-4-boronic acid
Synonyms:
  • PYRIDYL-4-BORONIC ACID
  • PYRIDINE-4-BORONIC ACID
  • PYRIDINE-4-BORONIC ACID HYDRATE
  • PYRIDIN-4-YLBORONIC ACID
  • PYRIDIN-4-YL-4-BORONIC ACID
  • RARECHEM AH PB 0240
  • TIMTEC-BB SBB004280
  • AKOS BRN-0273
CAS:
1692-15-5
MF:
C5H6BNO2
MW:
122.92
EINECS:
671-679-4
Product Categories:
  • Heterocyclic Compounds
  • B (Classes of Boron Compounds)
  • blocks
  • BoronicAcids
  • Pyridines
  • Boronic acid
  • Miscellaneous
  • Boronic Acids & Esters
  • Boronic acids
  • Organoborons
  • Pyridine
  • Aromatics
  • Boron Derivatives
  • Heterocycles
  • Boronic Acids & Esters
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Heteroaryl
  • Boronate Ester
  • Potassium Trifluoroborate
Mol File:
1692-15-5.mol
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Pyridine-4-boronic acid Chemical Properties

Melting point:
>300 °C (lit.)
Boiling point:
308.8±34.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Aqueous Acid (Slightly), Water (Slightly)
form 
Solid
pka
7.59±0.10(Predicted)
color 
White to Off-White
BRN 
471944
InChIKey
QLULGIRFKAWHOJ-UHFFFAOYSA-N
CAS DataBase Reference
1692-15-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,Xi,C,F
Risk Statements 
36/37/38-22-34-11
Safety Statements 
22-24/25-36/37/39-26-45-16
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339900

MSDS

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Pyridine-4-boronic acid Usage And Synthesis

Uses

Pyridine-4-boronic acid can be used as a candidate for Suzuki-Miyaura coupling reaction. Especially, as a N-containing building blocks, pyridine-4-boronic acid was employed to construct some heterocyclic compounds with superior biological activities.

Description

Pyridine-4-boronic acid is a kind of boronic acid derivative. It is useful building blocks in crystal engineering. It can also be used as a catalyst to act as a dehydrative condensation agent to synthesize amides using carboxylic acid and amines as raw materials. Its derivative, polystyrene-bound 4-pyridineboronic acid, is a useful catalyst for amidation reaction and esterification of alpha-hydrocarboxylic acids.

Chemical Properties

light orange granular powder

Uses

suzuki reaction

Uses

Reagent used for

  • Palladium-catalyzed Suzuki-Miyaura coupling reactions
  • Ligand-free palladium-catalyzed Suzuki coupling reaction under microwave irradation

Reagent used in Preparation of
  • HIV-1 protease inhibitors
  • Potential cancer threapeutics, such as PDK1 and protein kinase CK2 inhibitors

Uses

Boronic acid derivatives and their binding affinities with diols.

References

http://www.wako-chem.co.jp/english/labchem/product/Org/pyridineboronic/
José J. CamposGaxiola et al. "Pyridineboronic Acids as Useful Building Blocks in Combination with Perchloroplatinate(II) and -(IV) Salts: 1D, 2D, and 3D Hydrogen-Bonded Networks Containing X-H•••Cl2Pt− (X = C, N+), B(OH)2•••Cl2Pt−, and B(OH)2•••(HO)2B Synthons." Crystal Growth & Design 10.7(2010).
Kara, H., A. G. Orpen, and T. J. Podesta. "Pyridine boronic acids as building blocks in crystal engineering." Acta Crystallographica 61.Suppl (2001): C357.

Pyridine-4-boronic acid Preparation Products And Raw materials

Preparation Products

Pyridine-4-boronic acidSupplier

Wuxi Kehua Biological Technology Co., Ltd. Gold
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0510-0510-86838766
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Suzhou You Boron Photoelectric Material Co., Ltd. Gold
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15301358979
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
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INTATRADE GmbH
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+49 3493/605464
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sales@intatrade.de