Pyridine-4-boronic acid
Pyridine-4-boronic acid Basic information
- Product Name:
- Pyridine-4-boronic acid
- Synonyms:
-
- PYRIDYL-4-BORONIC ACID
- PYRIDINE-4-BORONIC ACID
- PYRIDINE-4-BORONIC ACID HYDRATE
- PYRIDIN-4-YLBORONIC ACID
- PYRIDIN-4-YL-4-BORONIC ACID
- RARECHEM AH PB 0240
- TIMTEC-BB SBB004280
- AKOS BRN-0273
- CAS:
- 1692-15-5
- MF:
- C5H6BNO2
- MW:
- 122.92
- EINECS:
- 671-679-4
- Product Categories:
-
- Heterocyclic Compounds
- B (Classes of Boron Compounds)
- blocks
- BoronicAcids
- Pyridines
- Boronic acid
- Miscellaneous
- Boronic Acids & Esters
- Boronic acids
- Organoborons
- Pyridine
- Aromatics
- Boron Derivatives
- Heterocycles
- Boronic Acids & Esters
- Boronic Acids
- Boronic Acids and Derivatives
- Heteroaryl
- Boronate Ester
- Potassium Trifluoroborate
- Mol File:
- 1692-15-5.mol
Pyridine-4-boronic acid Chemical Properties
- Melting point:
- >300 °C (lit.)
- Boiling point:
- 308.8±34.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Aqueous Acid (Slightly), Water (Slightly)
- form
- Solid
- pka
- 7.59±0.10(Predicted)
- color
- White to Off-White
- BRN
- 471944
- InChIKey
- QLULGIRFKAWHOJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 1692-15-5(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,Xi,C,F
- Risk Statements
- 36/37/38-22-34-11
- Safety Statements
- 22-24/25-36/37/39-26-45-16
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29339900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Pyridine-4-boronic acid Usage And Synthesis
Uses
Pyridine-4-boronic acid can be used as a candidate for Suzuki-Miyaura coupling reaction. Especially, as a N-containing building blocks, pyridine-4-boronic acid was employed to construct some heterocyclic compounds with superior biological activities.
Description
Pyridine-4-boronic acid is a kind of boronic acid derivative. It is useful building blocks in crystal engineering. It can also be used as a catalyst to act as a dehydrative condensation agent to synthesize amides using carboxylic acid and amines as raw materials. Its derivative, polystyrene-bound 4-pyridineboronic acid, is a useful catalyst for amidation reaction and esterification of alpha-hydrocarboxylic acids.
Chemical Properties
light orange granular powder
Uses
suzuki reaction
Uses
Reagent used for
- Palladium-catalyzed Suzuki-Miyaura coupling reactions
- Ligand-free palladium-catalyzed Suzuki coupling reaction under microwave irradation
Reagent used in Preparation of
- HIV-1 protease inhibitors
- Potential cancer threapeutics, such as PDK1 and protein kinase CK2 inhibitors
Uses
Boronic acid derivatives and their binding affinities with diols.
References
http://www.wako-chem.co.jp/english/labchem/product/Org/pyridineboronic/
José J. CamposGaxiola et al. "Pyridineboronic Acids as Useful Building Blocks in Combination with Perchloroplatinate(II) and -(IV) Salts: 1D, 2D, and 3D Hydrogen-Bonded Networks Containing X-H•••Cl2Pt− (X = C, N+), B(OH)2•••Cl2Pt−, and B(OH)2•••(HO)2B Synthons." Crystal Growth & Design 10.7(2010).
Kara, H., A. G. Orpen, and T. J. Podesta. "Pyridine boronic acids as building blocks in crystal engineering." Acta Crystallographica 61.Suppl (2001): C357.
Pyridine-4-boronic acid Preparation Products And Raw materials
Preparation Products
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Pyridine-4-boronic acid(1692-15-5)Related Product Information
- 4-Pyridineboronic acid pinacol ester
- Orthoboric acid
- 4-Methylpyridine
- Chromium picolinate
- Zinc borate
- 3-Pyridylboronic acid
- Sulfasalazine
- Methyl propyl carbonate
- (+/-)-NICOTINE
- 3-Pyridylacetic acid hydrochloride
- 2-Pyridinecarboxaldehyde
- Pyridine-2-carbonyl chloride hydrochloride
- 2-(Hydroxymethyl)pyridine
- ISONICOTINOYL CHLORIDE HYDROCHLORIDE
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- 2-PYRIDINEMETHANOL HYDROCHLORIDE
- Pyridine hydrochloride
- Pyridine hydrobromide