4-Chloro-N-methylpicolinamide Chemical Properties

Melting point:

41-43°C

Boiling point:

317.8±27.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met

form 

Solid

pka

13.41±0.46(Predicted)

color 

Off-White to Light Yellow

CAS DataBase Reference

220000-87-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

HS Code 

2933399990

MSDS

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4-Chloro-N-methylpicolinamide Usage And Synthesis

Description

4-Chloro-N-methylpicolinamide is a polar organic compound that interacts with hydrogen bonds. It has been shown to inhibit the value-added of cancer cells by inhibiting protein synthesis to inhibit the growth of human hepatocellular carcinoma cells, bcr/abl kinase, and hct116 cells, and is a candidate for cancer treatment. Studies have shown that it also inhibits the proliferation of MDA-MB231 breast cancer cells by blocking growth factor activity. In addition, 4-Chloro-N-methylpicolinamide is a pharmaceutical intermediate component used in the preparation of the antineoplastic drugs regorafenib and sorafenib.

Chemical Properties

Pale-Yellow Solid

Uses

4-Chloro-N-methylpyridine-2-carboxamide (>90%) (cas# 220000-87-3) is a compound useful in organic synthesis.

4-Chloro-N-methylpicolinamide(220000-87-3)Related Product Information

• Methylparaben
• N,N-Dimethylformamide
• Thiophanate-methyl
• Kresoxim-methyl
• Methyl acrylate
• Methyl acetate
• Bensulfuron methyl
• N-Methylformamide
• 2-Picoline
• PYRIDINE-2-CARBOXAMIDE
• 2,2'-(Butylimino)diethanol
• N-Benzylethanolamine
• 3-Amino-2-chlorobenzotrifluoride
• Methyl
• Sorafenib IMpurity
• Sorafenib related coMpound 8
• Sorafenib related compound 10
• Sorafenib Related Compound 21