2-Bromopyridine-4-carboxylic acid Chemical Properties

Melting point:

229-231°C

Boiling point:

447.2±30.0 °C(Predicted)

Density 

1.813±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.98±0.10(Predicted)

form 

Crystals or Crystalline Powder

color 

White

BRN 

471895

InChI

InChI=1S/C6H4BrNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)

InChIKey

YBTKGKVQEXAYEM-UHFFFAOYSA-N

SMILES

C1(Br)=NC=CC(C(O)=O)=C1

CAS DataBase Reference

66572-56-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

2-Bromopyridine-4-carboxylic acid Usage And Synthesis

Chemical Properties

White to light brown powder

Uses

2-Bromoisonicotinic acid (CAS 66572-56-3) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Application

2-Bromopyridine-4-carboxylic acid is a kind of Pyridine carboxylic acid compounds, it can be used in medicine synthesis.

Health Hazard

Accidental contact with 2-Bromopyridine-4-carboxylic acid causes skin irritation and serious eye irritation.

Synthesis

General procedure for the synthesis of 2-bromo-4-pyridinecarboxylic acid from 2-bromo-4-methylpyridine: To a stirred solution of 29.0 g (69 mmol) of 2-bromo-4-methylpyridine dissolved in 150 mL of concentrated sulfuric acid was added batchwise 67.9 g (231 mmol) of potassium dichromate. The reaction was cooled using an ice bath to maintain a constant temperature. After addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was slowly poured into 2 L of ice water and stirred at room temperature for 1 hour. The resulting crystals were collected by filtration, washed with water until the eluent was colorless, and finally dried under vacuum to give 30.0 g (88% yield) of 2-bromo-4-pyridinecarboxylic acid.

References

[1] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 17; 18
[2] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 36; 37
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[4] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 9; 24
[5] Polyhedron, 2016, vol. 118, p. 159 - 170

2-Bromopyridine-4-carboxylic acid(66572-56-3)Related Product Information

• 6-BROMOPYRIDINE-2-CARBOXYLIC ACID
• 2-Bromo-4-methylpyridine
• 2-Bromo-3-methylbenzaldehyde
• 2-Bromo-4-nitroimidazole
• 2-Bromo-4-fluoropyridine
• 2-Bromo-5,6-diphenylpyrazine
• 2-Bromo-3-trifluoromethylpyridine
• 2-Bromo-4-chloropyridine
• 2-Bromo-3-fluoropyridine
• 3-Amino-2-bromopyridine
• BenzenaMine, 2-broMo-5-fluoro-4-nitro-
• 2-Bromo-3,5-dichloropyridine
• Pyridine, 2-bromo-3,5-dichloro-6-methyl-
• 5-Amino-2-bromo-3-methylpyridine
• 2-Bromo-3-methyl-5-chloropyridine
• 2-Bromo-3-methyl-5-nitropyridine
• 2-Bromo-3-nitropyridine
• 2-BROMO-3-CHLORO-5-NITROPYRIDINE