Flumethrin Chemical Properties

Melting point:

<25 °C

Boiling point:

593.6±50.0 °C(Predicted)

Density 

1.342±0.06 g/cm3(Predicted)

refractive index 

nD25 1.5831

Flash point:

104 °C

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly, Sonicated)

JECFA Number

85

InChI

InChI=1S/C28H22Cl2FNO3/c1-28(2)21(15-22(30)17-8-11-19(29)12-9-17)26(28)27(33)35-25(16-32)18-10-13-23(31)24(14-18)34-20-6-4-3-5-7-20/h3-15,21,25-26H,1-2H3

InChIKey

YXWCBRDRVXHABN-JCMHNJIXSA-N

SMILES

C1(C(OC(C#N)C2=CC=C(F)C(OC3=CC=CC=C3)=C2)=O)C(C=C(Cl)C2=CC=C(Cl)C=C2)C1(C)C

CAS DataBase Reference

69770-45-2(CAS DataBase Reference)

EPA Substance Registry System

Cyclopropanecarboxylic acid, 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl (69770-45-2)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-36/38-43

Safety Statements 

28-36/37-45

RIDADR 

2902

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29269090

Flumethrin Usage And Synthesis

Description

Flumethrin: an ectoparasiticide.
Flumethrin is an ectoparasiticide that belongs to the group of α-cyano-pyrethroids and has been registered in EU member states for use on companion and food-producing animals since 1986. These chemicals have been combined in a slow-release matrix collar formulation incorporating 10% imidacloprid (w/w) and 4.5% flumethrin (w/w). The imidacloprid component of the collar is aimed at the treatment and control of fleas and lice, and the flumethrin component is aimed at the treatment and control of ticks and mites. The medicated collar is expected to provide sustained protection over eight months to dogs exposed to ticks, fleas and lice[1-2].

Uses

Flumethrin is a synthetic pyrethroid insecticide used in the control of parasites, particularly ticks, on cattle, sheep, goats, horses, and dogs. Flumethrin is also used for control of mites in beehiv es.

Uses

Insecticide; acaricide.

Definition

ChEBI: Flumethrin is an organochlorine acaricide, an organofluorine acaricide and a member of monochlorobenzenes. It has a role as a pyrethroid ester acaricide and a pyrethroid ester insecticide.

Metabolism

Opposite to e.g. permethrin and deltamethrin, the metabolism of flumethrin is simple without the need for glucuronidation. Flumethrin itself or its main metabolite, flumethrin acid, can be excreted without conjugation via feces. Moreover, flumethrin acid is pharmacologically inactive. The decreased feline glucuronidation rate is, therefore, toxicologically irrelevant. Accordingly, the NOAEL (No Observed Adverse Effect Level) for flumethrin is identical for dogs and cats. The already rather low flumethrin toxicity in cats is complemented in this new product by two other aspects: only a very low hair coat concentration of this highly effective acaricide is necessary for high efficacy against ticks, and this low amount is released steadily from the collar without peak concentrations[2].

References

[1] Dorothee Stanneck. “Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto?) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe.” Parasites & Vectors 5 (2012): 66.
[2] Dorothee Stanneck. “Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs.” Parasites & Vectors 5 (2012): 102.

Flumethrin(69770-45-2)Related Product Information

• ETHANE
• Dimethyl sebacate
• CHLORODIMETHYLVINYLSILANE
• Cyclopropane
• Bifenthrin
• Dimethyl sulfoxide
• N,N-Dimethylformamide
• Cyhalothrin
• Chlorodimethylphenylsilane
• 2-Chlorofluorobenzene
• Dimethyl fumarate
• Cyhalothrin
• Dimethyl ether
• FLUCYTHRINATE
• Dimethyl phthalate
• FENFLUTHRIN
• 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE
• Dimethyl carbonate