gne-131
gne-131 Basic information
- Product Name:
- gne-131
- Synonyms:
-
- gne-131
- GNE-131;GNE131;GNE 131
- CS-2887
- Cyclopropanesulfonamide, N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-
- N-[6-Cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide
- Na+ channels,inhibit,GNE131,Na channels,Inhibitor,Sodium Channel,GNE-131,GNE 131
- N-(7-(Adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)cyclopropanesulfonamide
- GNE-131, 10 mM in DMSO
- CAS:
- 1629063-81-5
- MF:
- C23H30N4O3S
- MW:
- 442.57
- Mol File:
- 1629063-81-5.mol
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gne-131 Chemical Properties
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (282.44 mM)
- form
- Solid
- pka
- 4.06±0.30(Predicted)
- color
- Light yellow to yellow
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gne-131 Usage And Synthesis
Uses
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
in vivo
GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1].
IC 50
Nav1.7: 3 nM (IC50)
References
[1] Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14 DOI:10.1021/acs.jmedchem.7b01826
gne-131Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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