LY-3154207
LY-3154207 Basic information
- Product Name:
- LY-3154207
- Synonyms:
-
- LY-3154207
- 2-(2,6-dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one
- LY-3154207,LY3154207
- Ethanone, 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3,4-dihydro-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-2(1H)-isoquinolinyl]-
- 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one , LY3154207
- mevidalen
- CAS:
- 1638667-79-4
- MF:
- C24H29Cl2NO3
- MW:
- 450.4
- Mol File:
- 1638667-79-4.mol
More
Less
LY-3154207 Chemical Properties
- Boiling point:
- 628.4±55.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 110 mg/mL (244.23 mM; Need ultrasonic)
- pka
- 14.60±0.10(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
LY-3154207 Usage And Synthesis
Uses
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1].
References
[1] Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Po DOI:10.1021/acs.jmedchem.9b01234
LY-3154207Supplier
Kaixin Chemical (Hong Kong) Limited
- Tel
- 010-88886666-01 13112345678
- loyson@tcypharm.com
Jinan Kabotang Biological Technology Co.,Ltd.
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Beijing xinyanhui pharmaceutical research and development co., LTD
- Tel
- 13969155946
- 1461866103@qq.com
Guangzhou Younan Technology Co., Ltd
- Tel
- 020-82000279 18988941452
- YN_research@163.com