UPGL00004
UPGL00004 Basic information
- Product Name:
- UPGL00004
- Synonyms:
-
- UPGL00004
- UPGL00004,UPGL-00004
- Benzeneacetamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-
- 2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide
- 2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide , UPGL00004
- UPGL00004, 10 mM in DMSO
- CAS:
- 1890169-95-5
- MF:
- C25H26N8O2S2
- MW:
- 534.66
- Mol File:
- 1890169-95-5.mol
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UPGL00004 Chemical Properties
- Density
- 1.460±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 9.23±0.50(Predicted)
- color
- Off-white to gray
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UPGL00004 Usage And Synthesis
Biological Activity
UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.
in vitro
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.
in vivo
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.
target
| Target | Value |
| glutaminase C (Cell-free assay) | < td class="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM
UPGL00004Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
MQ (shanghai) Pharmaceuticals Co., Ltd.
- Tel
- 13761635123
- 1014988033@qq.com