CA-5f
CA-5f Basic information
- Product Name:
- CA-5f
- Synonyms:
-
- CA-5f
- CA-5F;CA 5F;CA5F;1370032-19-1
- 4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- -5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- (E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one
- CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f
- (3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
- CA-5f, 10 mM in DMSO
- CAS:
- 1370032-19-1
- MF:
- C24H24N2O3
- MW:
- 388.46
- Product Categories:
-
- API
- Mol File:
- 1370032-19-1.mol
CA-5f Chemical Properties
- Boiling point:
- 639.7±55.0 °C(Predicted)
- Density
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 16.06±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
CA-5f Usage And Synthesis
Uses
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1].
Biological Activity
CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity.
in vivo
CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
| Animal Model: | < td class="col2"> Nude mice bearing A549 lung cancer cells|
| Dosage: | 40 mg /kg |
| Administration: | Injected via caudal vein, every 2 days for up to 30 days < /td> |
| Result: | Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice . |
target
Macroautophagy/autophagy
References
[1] Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406. DOI:10.1080/15548627.2018.1511503
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