PHOSPHATIDYLETHANOL
PHOSPHATIDYLETHANOL Basic information
- Product Name:
- PHOSPHATIDYLETHANOL
- Synonyms:
-
- 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL
- PHOSPHATIDYLETHANOL
- CAS:
- 765260-45-5
- MF:
- C41H79O9P
- MW:
- 747.03
- Mol File:
- Mol File
PHOSPHATIDYLETHANOL Chemical Properties
- storage temp.
- -20°
- solubility
- Soluble in Chloroform (up to 10 mg/ml).
- form
- Viscous oil / waxy solid
- Stability:
- Stable for 2 years from date of purchase as supplied. Phosphatidylethanol is subject to oxidation and must be protected from exposure to air. Solutions in chloroform may be stored at -20° for up to 3 months.
PHOSPHATIDYLETHANOL Usage And Synthesis
Description
Phosphatidlyethanol is an endogenous metabolite of phosphatidylcholine. Phospholipase D converts phosphatidylcholine to phosphatidylethanol in the presence of ethanol. This reaction is the basis of a sensitive and selective assay for PLD activity in intact cells for which this product may be used as a chromatographic standard.
References
1) Kobayashi et al. (1987), Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D; J. Neurochem., 48 1597 2) Liscovith et al. (1989), Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C; J. Biol. Chem., 264 1450 3) Pai et al. (1988), Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes; J. Biol. Chem., 263 12472