10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Chemical Properties

Melting point:

186-189°C

Boiling point:

431.3±55.0 °C(Predicted)

Density 

1.336

Flash point:

2℃

storage temp. 

-20°C

solubility 

Soluble to 100 mM in DMSO and to 50 mM in ethanol

form 

Solid

pka

13.75±0.20(Predicted)

color 

White to off-white

BRN 

1540211

InChIKey

BMPDWHIDQYTSHX-UHFFFAOYSA-N

CAS DataBase Reference

29331-92-8

Safety Information

Hazard Codes 

N,Xn,F

Risk Statements 

51/53-36-20/21/22-11

Safety Statements 

61-36/37-26-16

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Usage And Synthesis

Chemical Properties

White Solid

Uses

A metabolite of Oxcarbazepine

Uses

A labelled metabolite of Oxcarbazepine

Uses

10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.

Definition

ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.

storage

Store at RT