FASCAPLYSIN CHLORIDE Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)

form 

solid

color 

Dark red-brown

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-61-45-20/21/22

Safety Statements 

26-53-45-36/37/39

FASCAPLYSIN CHLORIDE Usage And Synthesis

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

References

1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377

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