FASCAPLYSIN CHLORIDE Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)

form 

solid

color 

Dark red-brown

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-61-45-20/21/22

Safety Statements 

26-53-45-36/37/39

FASCAPLYSIN CHLORIDE Usage And Synthesis

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

in vivo

IC 50

CDK4

References

[1] RAJEEV SONI. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 877-884. DOI:10.1006/bbrc.2000.3349
[2] JING LIN  Hai M C  Xiao Jun Yan. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.[J]. Cancer Chemotherapy and Pharmacology, 2007, 59 4: 439-445. DOI:10.1007/s00280-006-0282-x
[3] HAMILTON G. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.[J]. Marine Drugs, 2014: 1377-1389. DOI:10.3390/md12031377

FASCAPLYSIN CHLORIDE(114719-57-2)Related Product Information

• CASTANOSPERMINE
• Sorafenib tosylate
• Sunitinib Malate
• BORRELIDIN
• NORHARMANE HYDROCHLORIDE
• N-PHENYLPYRIDINIUM CHLORIDE
• HARMAN HYDROCHLORIDE
• FASCAPLYSIN CHLORIDE