FASCAPLYSIN CHLORIDE

Product Name: FASCAPLYSIN CHLORIDE
CAS No.: 114719-57-2
Chemical Name: FASCAPLYSIN CHLORIDE
Synonyms: fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Fascaplysin, ATP-competitve CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI);3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one
CBNumber: CB0503495
Molecular Formula: C18H11ClN2O
Formula Weight: 306.74574
MOL File: 114719-57-2.mol

More

Less

FASCAPLYSIN CHLORIDE Property

storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
form: solid
color: Dark red-brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

More

Less

Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-61-45-20/21/22
Safety Statements: 26-53-45-36/37/39

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 341251
Product name: Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem
Packaging: 1mg
Price: $140
Updated: 2023/01/07

Cayman Chemical

Product number: 21715
Product name: Fascaplysin (chloride)
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 21715
Product name: Fascaplysin (chloride)
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

TRC

Product number: F150013
Product name: FascaplysinChloride
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573160
Product name: Fascaplysin (chloride)|CDK4 inhibitor
Packaging: 1g
Price: $3580.2
Updated: 2021/12/16

More

Less

FASCAPLYSIN CHLORIDE Chemical Properties,Usage,Production

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

in vivo

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo^[2]

IC 50

CDK4

References

[1] RAJEEV SONI. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 877-884. DOI:10.1006/bbrc.2000.3349
[2] JING LIN Hai M C Xiao Jun Yan. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.[J]. Cancer Chemotherapy and Pharmacology, 2007, 59 4: 439-445. DOI:10.1007/s00280-006-0282-x
[3] HAMILTON G. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.[J]. Marine Drugs, 2014: 1377-1389. DOI:10.3390/md12031377

FASCAPLYSIN CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

FASCAPLYSIN CHLORIDE Suppliers

China 15 Switzerland 1 United Kingdom 2 United States 8 USA 1 Global 27

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Guangzhou Aoz Biotechnology Co., Ltd.

Tel: 18022383332
Country: CHINA
ProdList: 0
Advantage: 58

114719-57-2, FASCAPLYSIN CHLORIDERelated Search:

CASTANOSPERMINE Sorafenib tosylate Sunitinib Malate BORRELIDIN NORHARMANE HYDROCHLORIDE N-PHENYLPYRIDINIUM CHLORIDE HARMAN HYDROCHLORIDE FASCAPLYSIN CHLORIDE

Fascaplysin (chloride)|CDK4 inhibitor

12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride

fascaplysine

Fascaplysin chloride hydrate

Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)

FASCAPLYSIN CHLORIDE

Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride

Fascaplysin, ATP-competitve CDK4 inhibitor

3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one

114719-57-2

C18H11ClN2OxH2O

C18H11ClN2O