ChemicalBook > CAS DataBase List > HARMAN HYDROCHLORIDE

HARMAN HYDROCHLORIDE

Product Name
HARMAN HYDROCHLORIDE
CAS No.
21655-84-5
Chemical Name
HARMAN HYDROCHLORIDE
Synonyms
harmane hcl;HARMAN HYDROCHLORIDE;HARMANE HYDROCHLORIDE;ARIBINE HYDROCHLORIDE;METHYL-4-CARBOLINE HYDROCHLORIDE;harman hydrochloride monohydrate;1-Methyl-9H-pyrido[3,4-b]indole.HCl;Harman hydrochloride, 10 mM in DMSO;1-methyl-9H-beta-carboline hydrochloride;Harmane hydrochloride(486-84-0 Free base)
CBNumber
CB4354518
Molecular Formula
C12H11ClN2
Formula Weight
218.68
MOL File
21655-84-5.mol
More
Less

HARMAN HYDROCHLORIDE Property

Melting point:
290°C
storage temp. 
Sealed in dry,Room Temperature
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0370290
Product name
HARMANE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$724.93
Updated
2021/12/16
SynChem
Product number
SC-42104
Product name
HARMAN HYDROCHLORIDE
Purity
95%
Packaging
1g
Price
$250
Updated
2021/12/16
AHH
Product number
MT-14386
Product name
Harmanhydrochloride
Purity
98%
Packaging
10g
Price
$388
Updated
2021/12/16
Alichem
Product number
21655845
Product name
1-Methyl-9H-pyrido[3,4-b]indolehydrochloride
Packaging
1g
Price
$400
Updated
2021/12/16
Crysdot
Product number
CD11165111
Product name
1-Methyl-9H-pyrido[3,4-b]indolehydrochloride
Purity
95+%
Packaging
5g
Price
$634
Updated
2021/12/16
More
Less

HARMAN HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF)[1][2][3][4][5][6].

in vivo

Harman (0-12.5mg/kg, i.v., single dose) has an ED50 of 3.6 mg/kg for convulsant activity in rats. Its anticonvulsant effect lasts for a short time and delays the reaction time to pain[1].
Harman (0.01-1 nM, injected into rostralventrolateral medulla, single dose) caused a decrease in blood pressure in rats[2].
Harman (2.5-10 mg/kg, i.p., single dose) had anxiolytic and antidepressant effects in rats[5].

Animal Model:Female Wistar rats[1]
Dosage:0, 3.125, 6.25 mg/kg, single dose; 0, 1.56, 3.125, 6 25, 12.5 mg/kg, single dose; 0, 1.56, 3.125, 6.25 mg/kg, single dose
Administration:Intravenous injection (i.v.)
Result:Delayed apamorphine-induced licking.
Increased body temperature in rats, reaching the highest value in 25 minutes. 3.125 mg/kg or above caused hypothermia in a dose-dependent manner. Body temperature returned to the control level 100 minutes after injection of 3.125 or 6.25 mg/kg.
Prolonged the reaction time to nociception. At 3.125 mg/kg, a delay in reaction could be detected in 20 minutes.
Animal Model:β-carbon alkali-induced hypotension in rats[2]
Dosage:0.01-1 nM
Administration:Injection into RVLM (rostralventrolateral medulla)
Result:Caused a dose-dependent decrease in mean arterial pressure (MAP) without significant changes in heart rate (HR). Phaloxan could reverse the decrease in MAP.
Animal Model:Male adult Sprague-Dawley rats[5]
Dosage:2.5, 5.0, 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced the immobility time in the swimming test and increased the time in the open arms in the maze test dose-dependently.

IC 50

hMAO-A: 0.5 μM (IC50); MAO-B: 5 μM (IC50); α2-adrenergic receptor: 18 μM (IC50); I1-Imidazoline receptor: 30 nM (IC50); nAChR: 24 μM (IC50); benzodiazepine receptor: 7 nM (IC50); Opioid receptor: 2.8 μM (IC50); Loperamide: 163 μM (IC50); Serotonin: 101 μM (IC50)

References

[1] W E Müller, et al. On the neuropharmacology of harmane and other beta-carbolines. Pharmacol Biochem Behav. 1981 May;14(5):693-9. DOI:10.1016/0091-3057(81)90133-7
[2] Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. DOI:10.1038/sj.bjp.0703142
[3] Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications DOI:10.1007/BF01254930
[4] https://pubmed.ncbi.nlm.nih.gov/345280/
[5] E D Louis, et al. Harmane induces anxiolysis and antidepressant-like effects in rats. Ann N Y Acad Sci. 2005 Aug 9;65(3):391-6. DOI:10.1196/annals.1304.024
[6] Yoo Jung Yang, et al. Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Eur J Pharmacol. 2008 Jun 10;587(1-3):57-64. DOI:10.1016/j.ejphar.2008.03.050

HARMAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

HARMAN HYDROCHLORIDE Suppliers

China 26 Germany 2 Switzerland 1 United Kingdom 3 United States 6 Global 38
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
More
Less

View Lastest Price from HARMAN HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
1-methyl-9H-pyrido[3,4-b]indole,hydrochloride 21655-84-5
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

21655-84-5, HARMAN HYDROCHLORIDERelated Search:

HARMANE 9H-PYRIDO[3,4-B]INDOLE HARMOL HYDROCHLORIDE HARMINE HYDROCHLORIDE ZERENEX E/6026461 HARMOL HYDROCHLORIDE DIHYDRATE FASCAPLYSIN CHLORIDE BANISTERINE MONOHYDRATE N-(4-CHLOROPHENYL)-1-METHYL-9H-BETA-CARBOLINE-3-CARBOXAMIDE HARMAN HYDROCHLORIDE

  • 1-Methyl-9H-pyrido[3,4-b]indole.HCl
  • harman hydrochloride monohydrate
  • 4-b)indole,1-methyl-9h-pyrido(monohydrochloride
  • METHYL-4-CARBOLINE HYDROCHLORIDE
  • ARIBINE HYDROCHLORIDE
  • HARMANE HYDROCHLORIDE
  • HARMAN HYDROCHLORIDE
  • harmane hcl
  • 1-methyl-9H-pyrido[3,4-b]indole hydrochloride
  • 1-methyl-9H-beta-carboline hydrochloride
  • 1-methyl-9H-pyrido[3,4-b]indol hydrochloride
  • Harmane hydrochloride(486-84-0 Free base)
  • Harman hydrochloride, 10 mM in DMSO
  • 21655-84-5
  • C12H10N2xHCl
  • C12H11N2Cl
  • C12H10N2HCl
  • Imidazoline binding site