HARMANE
- Product Name
- HARMANE
- CAS No.
- 486-84-0
- Chemical Name
- HARMANE
- Synonyms
- HARMAN;1-METHYL-9H-PYRIDO[3,4-B]INDOLE;1-METHYL-PYRIDO[3,4-B]INDOLE;Aribin;ARIBINE;HARMANE;Indoter;Loturine;NSC 54439;Locuturin
- CBNumber
- CB9698060
- Molecular Formula
- C12H10N2
- Formula Weight
- 182.22
- MOL File
- 486-84-0.mol
HARMANE Property
- Melting point:
- 235-238 °C(lit.)
- Boiling point:
- 305.62°C (rough estimate)
- Density
- 1.1485 (rough estimate)
- refractive index
- 1.6266 (estimate)
- storage temp.
- Store at RT
- solubility
- methanol: soluble50mg/ml
- pka
- 7.37, 14.6(at 25℃)
- form
- Solid
- color
- White to Dark Brown
- Water Solubility
- 1523g/L(20 ºC)
- Merck
- 13,4630
- BRN
- 143898
- LogP
- 3.100
- CAS DataBase Reference
- 486-84-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21-36/37/38
- Safety Statements
- 22-24/25-36-26
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- UV0280000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 i.p. in mice: 50 mg/kg (Sigg)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 103276
- Product name
- Harmane
- Purity
- 98%
- Packaging
- 1g
- Price
- $246
- Updated
- 2024/03/01
- Product number
- 29613
- Product name
- Harmane
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 29613
- Product name
- Harmane
- Packaging
- 500mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- 29613
- Product name
- Harmane
- Packaging
- 100mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 29613
- Product name
- Harmane
- Packaging
- 1g
- Price
- $226
- Updated
- 2024/03/01
HARMANE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
- Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
- It was used to study interactions of norharman and harman with DNA.
- It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Uses
Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans.
Definition
ChEBI: An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, P ssiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.
Synthesis Reference(s)
The Journal of Organic Chemistry, 37, p. 1429, 1972 DOI: 10.1021/jo00974a030
Tetrahedron, 49, p. 3325, 1993 DOI: 10.1016/S0040-4020(01)90161-9
General Description
- Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
- It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
- Blood harmane concentration is elevated in essential tremor, late-life neurological disease.
Biological Activity
Proposed as the endogenous ligand for imidazoline binding sites. Binds to I 1 -sites in rat kidney with an IC 50 of 31 nM, and I 2 -sites with a K i of 49 nM. In vivo, produces a dose-dependent hypotension that is reversed by efaroxan (2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride ). Also a potent inhibitor of monoamine oxidases A and B (I 50 values are 0.5 and 5 μ M respectively).
Biochem/physiol Actions
I1 imidazoline binding site agonist.
storage
Room temperature
HARMANE Preparation Products And Raw materials
Raw materials
Preparation Products
HARMANE Suppliers
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View Lastest Price from HARMANE manufacturers
- Product
- Harmane 486-84-0
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09