Vasicine
- Product Name
- Vasicine
- CAS No.
- 6159-55-3
- Chemical Name
- Vasicine
- Synonyms
- PEGANINE;1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL;C10733;vasicin;VASICINE;ST012797;TOS-BB-0711;NCI60_030781;(-)-Vasicine;AKOS NCG1-0080
- CBNumber
- CB5300633
- Molecular Formula
- C11H12N2O
- Formula Weight
- 188.23
- MOL File
- 6159-55-3.mol
Vasicine Property
- Melting point:
- 211.5°C
- Boiling point:
- 323.23°C (rough estimate)
- Density
- 1.1124 (rough estimate)
- refractive index
- 1.5850 (estimate)
- solubility
- DMSO : 83.33 mg/mL (442.70 mM; Need ultrasonic)
- form
- Powder
- pka
- 13.08±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11760
- Product name
- Vasicine
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 11760
- Product name
- Vasicine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $191
- Updated
- 2021/12/16
- Product number
- 11760
- Product name
- Vasicine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $324
- Updated
- 2021/12/16
- Product number
- T304240
- Product name
- 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- V1716
- Product name
- Vasicine
- Packaging
- 1mg
- Price
- $160
- Updated
- 2021/12/16
Vasicine Chemical Properties,Usage,Production
Description
This quinazoline alkaloid was first isolated from the leaves of Adhatoda vasica
Nees by Hooper and subsequently discovered in Peganum harmala under the
name Peganine. The base is optically inactive although Spath and Kesztler have
reported the isolation of the (-)-form from the fresh leaves of A. vasica and
Rosenfeld and Kolesnikow have obtained the same form from the flowers and
stems of Peganum harmala. The salts are readily obtained crystalline, e.g. the
hydrochloride dihydrate, m.p. 208°C (dry); hydriodide dihydrate, m.p. 195°C
(dry); picrate, m.p. 199°C (dec.) and the methiodide, m.p. 187°C.
With AcOH, the alkaloid gives an anomalous acetyl derivative, m.p. 165°C,
subsequently shown to be N-acetylpedadiene. Oxidation with KMn04 gives
4-quinazolone and 4-keto-3 :4-dihydroxyquinazolyl-3-acetic acid, the latter
characterized as the methyl ester, m.p. 152°C.
The crude drug from A. vasica is used in India as a remedy for asthma while
the pure alkaloid acts as a bronchodilator.
Chemical Properties
White needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from camels.
Biological Activity
Vasicine, isolated from A. vasica, is an alkaloid. It is a natural cholinesterase (cholinesterase) inhibitor, has anticholinesterase activity in preclinical models, and can be used for the development of therapeutic drugs for Alzheimer's disease.
target
Antifection | AChR
References
Hooper., Pharm. J., 18,841 (1888)
Sen, Ghose.,J. Ind. Chem. Soc., 1,315 (1924)
Ghose., ibid, 4, 1 (1927)
Spath, Nakawitz., Ber., 67,45 (1934)
Spath, Kuffner., ibid, 67, 1494 (1934)
Narang, Ray., Chem. & Ind., 53,698 (1934)
Hanford, Liang, Adams., J. Amer. Chem. Soc., 56, 2780 (1934)
Ghoseetal., ibid, 57,921,951 (1935)
Rosenfeld, Kolesnikov., Ber., 69, 2022 (1936)
Pharmacology:
Chopra., Ind. Med. Gaz., 60, 354 (1925)
Tutaev, Makarova., Trans. Ukraine Inst. Exp. Pharm., 1,32 (1938)
Vasicine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Vasicine manufacturers
- Product
- VASICINE 6159-55-3
- Price
- US $1080.00/mg
- Min. Order
- 1mg
- Purity
- 98
- Supply Ability
- 5 Kg
- Release date
- 2024-04-01
- Product
- Vasicine 6159-55-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥97%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-12