FASCAPLYSIN CHLORIDE
- Product Name
- FASCAPLYSIN CHLORIDE
- CAS No.
- 114719-57-2
- Chemical Name
- FASCAPLYSIN CHLORIDE
- Synonyms
- fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Fascaplysin, ATP-competitve CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI);3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one
- CBNumber
- CB0503495
- Molecular Formula
- C18H11ClN2O
- Formula Weight
- 306.74574
- MOL File
- 114719-57-2.mol
FASCAPLYSIN CHLORIDE Property
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
- form
- solid
- color
- Dark red-brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-61-45-20/21/22
- Safety Statements
- 26-53-45-36/37/39
N-Bromosuccinimide Price
- Product number
- 341251
- Product name
- Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem
- Packaging
- 1mg
- Price
- $140
- Updated
- 2023/01/07
- Product number
- 21715
- Product name
- Fascaplysin (chloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 21715
- Product name
- Fascaplysin (chloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- F150013
- Product name
- FascaplysinChloride
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- KIN0001263
- Product name
- FASCAPLYSIN CHLORIDE HYDRATE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $659.25
- Updated
- 2021/12/16
FASCAPLYSIN CHLORIDE Chemical Properties,Usage,Production
Description
Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
Uses
Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.
in vivo
Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]
IC 50
CDK4
References
[1] RAJEEV SONI. Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 877-884. DOI:10.1006/bbrc.2000.3349
[2] JING LIN Hai M C Xiao Jun Yan. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.[J]. Cancer Chemotherapy and Pharmacology, 2007, 59 4: 439-445. DOI:10.1007/s00280-006-0282-x
[3] HAMILTON G. Cytotoxic effects of fascaplysin against small cell lung cancer cell lines.[J]. Marine Drugs, 2014: 1377-1389. DOI:10.3390/md12031377
FASCAPLYSIN CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
FASCAPLYSIN CHLORIDE Suppliers
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- Country
- Switzerland
- ProdList
- 6896
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