1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Basic information
- Product Name:
- 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
- Synonyms:
-
- ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate
- 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
- 3,6,9,12-Tetraoxa-13-thiatetradecan-1-ol 1-Methanesulfonate 13,13-Dioxide
- MS-PEG4-MS
- Ms-PEG5-Ms
- CAS_55400-73-2
- 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxaundecane
- 2-[2-[2-(2-methylsulfonyloxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
- CAS:
- 55400-73-2
- MF:
- C10H22O9S2
- MW:
- 350.41
- Product Categories:
-
- Cross Linking Reagents
- Nitric Oxide Reagents
- Mol File:
- 55400-73-2.mol
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1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Chemical Properties
- Boiling point:
- 533.6±45.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, Under Inert Atmosphere
- solubility
- Dichloromethane
- form
- Oil
- color
- Colorless
- CAS DataBase Reference
- 55400-73-2
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1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Usage And Synthesis
Description
Ms-PEG5-Ms are PEG linkers containing two mesyl moieties. The mesyl groups are good leaving groups and can also be used as protecting groups for primary alcohols. They can be deprotected in the presence of sodium amalgam. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Chemical Properties
Yellow Oil
Uses
Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
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