Basic information Safety Supplier Related

1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE

Basic information Safety Supplier Related

1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Basic information

Product Name:
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
Synonyms:
  • ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate
  • 1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
  • 3,6,9,12-Tetraoxa-13-thiatetradecan-1-ol 1-Methanesulfonate 13,13-Dioxide
  • MS-PEG4-MS
  • Ms-PEG5-Ms
  • CAS_55400-73-2
  • 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxaundecane
  • 2-[2-[2-(2-methylsulfonyloxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
CAS:
55400-73-2
MF:
C10H22O9S2
MW:
350.41
Product Categories:
  • Cross Linking Reagents
  • Nitric Oxide Reagents
Mol File:
55400-73-2.mol
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1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Chemical Properties

Boiling point:
533.6±45.0 °C(Predicted)
Density 
1.310±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility 
Dichloromethane
form 
Oil
color 
Colorless
CAS DataBase Reference
55400-73-2
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1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE Usage And Synthesis

Description

Ms-PEG5-Ms are PEG linkers containing two mesyl moieties. The mesyl groups are good leaving groups and can also be used as protecting groups for primary alcohols. They can be deprotected in the presence of sodium amalgam. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical Properties

Yellow Oil

Uses

Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANESupplier

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