Mes-PEG5- t-butyl ester
Mes-PEG5- t-butyl ester Basic information
- Product Name:
- Mes-PEG5- t-butyl ester
- Synonyms:
-
- Mes-PEG5- t-butyl ester
- MS-PEG5- t-butyl ester
- Mes-PEG4-t-butyl ester
- CAS_870487-48-2
- 4,7,10,13,16-Pentaoxa-17-thiaoctadecanoic acid, 1,1-dimethylethyl ester, 17,17-dioxide
- 3,6,9,12,15-Pentaoxa-2-thiaoctadecan-18-oic acid, 1,1-dimethylethylester, 2,2-dioxide
- tert-Butyl 1-(Methylsulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate
- CAS:
- 870487-48-2
- MF:
- C16H32O9S
- MW:
- 400.48
- Mol File:
- 870487-48-2.mol
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Mes-PEG5- t-butyl ester Chemical Properties
- Boiling point:
- 499.9±40.0 °C(Predicted)
- Density
- 1.147±0.06 g/cm3(Predicted)
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Mes-PEG5- t-butyl ester Usage And Synthesis
Description
Ms-PEG4-t-butyl ester is a PEG linker with a mesyl group and a t-butyl protecting group. Mesyl is a good leaving group and can participate in substitution reactions. The t-butyl group can be removed under acidic condtions. The hydrophilic PEG linker increases the solubility properties of compounds in aqueous media.
Uses
Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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