Hydroxy-PEG3-Mes Chemical Properties

Boiling point:

398.2±27.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

pka

14.36±0.10(Predicted)

Hydroxy-PEG3-Mes Usage And Synthesis

Biological Activity

Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Hydroxy-PEG3-Mes(139115-89-2)Related Product Information

• Mes-PEG5- t-butyl ester
• Mes-PEG5- THP
• Mes-PEG2-acid t-butyl ester
• Hydroxy-PEG14-t-butly ester
• 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid
• PEG4-acid
• Hydroxy-PEG7-t-butyl acetate
• Hydroxy-PEG5-t-butyl acetate
• PEG8-t-butly ester
• PEG14-t-butly ester