Mes-PEG2-acid t-butyl ester Chemical Properties

Boiling point:

429.2±30.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Liquid

color 

Colorless to light yellow

Mes-PEG2-acid t-butyl ester Usage And Synthesis

Description

Ms-PEG2-t-butyl ester is a PEG linker containing a mesyl group and a t-butyl protecting group. The mesyl group is a good leaving group for nucleophilic substitution reactions. The t-butyl is an acid labile protecting group. Upon removal, the carboxylic acid can react with primary amines. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Ms-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Mes-PEG2-acid t-butyl ester(1312309-62-8)Related Product Information

• Mes-PEG5- t-butyl ester
• Mes-PEG5- THP
• Hydroxy-PEG3-Mes