3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid Chemical Properties

Boiling point:

350.0±27.0 °C(Predicted)

Density 

1.196±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DMF

form 

A liquid

pka

4.27±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid Usage And Synthesis

Description

Hydroxy-PEG2-acid sodium salt is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid(1334286-77-9)Related Product Information

• α,ω-dipropionic acid tetraethylene glycol
• Bis-PEG6-acid
• Hydroxy-PEG3-t-butylester
• Hydroxy-PEG4-t-butyl ester
• Hydroxy-PEG9-t-butyl ester
• alpha-[3-(1,1-Dimethylethoxy)-3-oxopropyl]-omega-hydroxypoly(oxy-1,2-ethanediyl)
• HO-PEG8-CH2CH2COOH
• TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
• HO-PEG5-tBu
• Hydroxy-PEG5-acid
• PEG5-acid
• PEG14-t-butly ester
• Hydroxy-PEG3-Mes
• Hydroxy-PEG5-t-butyl acetate
• PEG4-acid
• Hydroxy-PEG2-CH2CO2H
• DBCO-Acid
• disulfo-ICG-carboxylic acid(tri-sulfo-cy7.5 COOH)