TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Basic information
- Product Name:
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- Synonyms:
-
- HO-PEG3-COOtBu
- Hydroxy-PEG3-(CH2)2-Boc
- OH-PEG3-CH2CH2COOtBu
- OH-PEG3-TBA
- HO-PEG3-t-Butyl ester
- tert-Butyl 3-(2-(2-(2-hydroxyethoxy)
- 12-HYDROXY-4 7 10-TRIOXA-
- Hydroxy-PEG4-t-butyles
- CAS:
- 186020-66-6
- MF:
- C13H26O6
- MW:
- 278.34
- Product Categories:
-
- peg
- Mol File:
- 186020-66-6.mol
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties
- Boiling point:
- 365.8±27.0 °C(Predicted)
- Density
- 1.052 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.446
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- BRN
- 7638988
- CAS DataBase Reference
- 186020-66-6
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Safety Information
- WGK Germany
- 3
- F
- 10
- HS Code
- 2918999090
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Usage And Synthesis
Description
Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Biological Activity
Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
| Alkyl/ether
|
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Supplier
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd Gold
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- 0431-80514535 19917294565
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Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd Gold
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- +86-021-50929289 86186163093
- sales@ypptech.com.cn
Hebei led the biological technology co., LTD Gold
- Tel
- 18032827359
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BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Jia Xing Isenchem Co.,Ltd
- Tel
- 0573-85285100 18627885956
- isenchem@163.com
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-(186020-66-6)Related Product Information
- Hydroxy-PEG4-t-butyl ester
- Bis-PEG6-t-butyl ester
- tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate
- alpha-Azido-omega-hydroxy octa(ethylene glycol)
- PENTAETHYLENE GLYCOL
- (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide
- alpha, oMega-Dipropionic acid hexaethylene glycol
- Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid
- FMoc-NH-8(ethylene glycol)-acetic acid
- FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
- HEPTAETHYLENE GLYCOL
- MPEG7-CH2CH2COOH
- Amino-PEG2-acid
- 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL
- Propargyl-PEG5-alcohol
- Triethylene Glycol Mono(2-propynyl) Ether
- Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
- HEPTAETHYLENE GLYCOL Monobenzyl ether