TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties

Boiling point:

365.8±27.0 °C(Predicted)

Density 

1.052 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.446

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO

form 

clear liquid

pka

14.36±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

BRN 

7638988

CAS DataBase Reference

186020-66-6

Safety Information

WGK Germany 

3

F 

10

HS Code 

2918999090

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Usage And Synthesis

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

in vitro

target

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-(186020-66-6)Related Product Information

• Hydroxy-PEG4-t-butyl ester
• Bis-PEG6-t-butyl ester
• tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate
• alpha-Azido-omega-hydroxy octa(ethylene glycol)
• PENTAETHYLENE GLYCOL
• (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide
• alpha, oMega-Dipropionic acid hexaethylene glycol
• Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid
• FMoc-NH-8(ethylene glycol)-acetic acid
• FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID
• HEPTAETHYLENE GLYCOL
• MPEG7-CH2CH2COOH
• Amino-PEG2-acid
• 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL
• Propargyl-PEG5-alcohol
• Triethylene Glycol Mono(2-propynyl) Ether
• Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
• HEPTAETHYLENE GLYCOL Monobenzyl ether