TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- Product Name
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- CAS No.
- 186020-66-6
- Chemical Name
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
- Synonyms
- HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
- CBNumber
- CB1497771
- Molecular Formula
- C13H26O6
- Formula Weight
- 278.34
- MOL File
- 186020-66-6.mol
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property
- Boiling point:
- 365.8±27.0 °C(Predicted)
- Density
- 1.052 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.446
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- BRN
- 7638988
- CAS DataBase Reference
- 186020-66-6
Safety
- WGK Germany
- 3
- F
- 10
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 83062
- Product name
- tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
- Purity
- ≥97.0%(GC)
- Packaging
- 5G
- Price
- $138.8
- Updated
- 2024/03/01
- Product number
- 83062
- Product name
- tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
- Purity
- ≥97.0%(GC)
- Packaging
- 1g
- Price
- $78.2
- Updated
- 2023/06/20
- Product number
- B5587
- Product name
- tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- B5587
- Product name
- tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $272
- Updated
- 2024/03/01
- Product number
- B809908
- Product name
- tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production
Description
Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Biological Activity
Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
Non-cleavable < span> | PEGs
| Alkyl/ether
|
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers
- Product
- Hydroxy-PEG3-t-butyl ester 186020-66-6
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-25
- Product
- TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- 186020-66-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04