TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Product Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
CAS No.: 186020-66-6
Chemical Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonyms: HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
CBNumber: CB1497771
Molecular Formula: C13H26O6
Formula Weight: 278.34
MOL File: 186020-66-6.mol

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property

Boiling point:: 365.8±27.0 °C(Predicted)
Density: 1.052 g/mL at 20 °C (lit.)
refractive index: n20/D 1.446
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: clear liquid
pka: 14.36±0.10(Predicted)
color: Colorless to Light yellow to Light orange
BRN: 7638988
InChI: InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
InChIKey: KSXVEOLRERRELV-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCO
CAS DataBase Reference: 186020-66-6

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Safety

WGK Germany: 3
F: 10
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 5G
Price: $298
Updated: 2025/07/31

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 1g
Price: $78.2
Updated: 2023/06/20

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 1g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 5g
Price: $272
Updated: 2025/07/31

TRC

Product number: B809908
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

Synthesis

1663-39-4

112-27-6

186020-66-6

Synthesis of Compound 71; Step a: Sodium metal (0.10 g, 4.35 mmol) was slowly added to an anhydrous tetrahydrofuran (250 mL) solution of triethylene glycol (64.0 mL, 0.48 mol) at room temperature. After the sodium was completely dissolved, tert-butyl acrylate (24.0 mL, 0.164 mol) was added dropwise to the system. The reaction mixture was stirred continuously at room temperature for 20 h. The reaction was subsequently neutralized with 1.0 N hydrochloric acid solution (4 mL). After removal of the solvent by distillation under reduced pressure, the residue was suspended in saturated aqueous sodium chloride solution and extracted with ethyl acetate (3 x 70 mL). The organic phases were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. After concentration under reduced pressure to remove the solvent, the tert-butyl acrylate adduct (40.23 g, 0.157 mol, 96% yield) was obtained as a colorless oil, which could be used for subsequent reactions without further purification. The product was analyzed by high performance liquid chromatography (HPLC): retention time t R = 10.2 min.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Alkyl/ether

References

[1] Patent: US2006/228325, 2006, A1. Location in patent: Page/Page column 63
[2] Patent: CN105524053, 2016, A. Location in patent: Paragraph 0468; 0469; 0470
[3] Journal of Organic Chemistry, 1997, vol. 62, # 4, p. 813 - 826
[4] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
[5] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 295

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Suppliers

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View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers

LAURENT

Product: HO-PEG3-CH2CH2COOtBu 186020-66-6
Price: US $7315.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

LAURENT

Product: HO-PEG3-CH2CH2COOtBu 186020-66-6
Price: US $7315.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Hydroxy-PEG3-(CH2)2-Boc 186020-66-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

186020-66-6, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Related Search:

Hydroxy-PEG4-t-butyl ester Bis-PEG6-t-butyl ester tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate alpha-Azido-omega-hydroxy octa(ethylene glycol) PENTAETHYLENE GLYCOL (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide alpha, oMega-Dipropionic acid hexaethylene glycol Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid FMoc-NH-8(ethylene glycol)-acetic acid FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID HEPTAETHYLENE GLYCOL MPEG7-CH2CH2COOH Amino-PEG2-acid 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL Propargyl-PEG5-alcohol Triethylene Glycol Mono(2-propynyl) Ether Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) Hydroxy-PEG3-ethyl ester

HO-PEG3-COOtBu

Hydroxy-PEG3-(CH2)2-Boc

OH-PEG3-CH2CH2COOtBu

OH-PEG3-TBA

HO-PEG3-t-Butyl ester

tert-Butyl 3-(2-(2-(2-hydroxyethoxy)

12-HYDROXY-4 7 10-TRIOXA-

Hydroxy-PEG4-t-butyles

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

HO-PEG3-tBu

HO-PEG3-CH2CH2COOtBu

3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester

tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)

Hydroxy-PEG4-t-butylester

Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

HO(CH2CH2O)3CH2CH2COOT-BU

tert-Butyl PEG3 propanoate

12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester

HO-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

OH-PEG3-(CH2)2-Boc

Hydroxy-PEG3-(CH2)2-Boc97

<i>tert</i>-Butyl 12-hydroxy-4,7,10-trioxadodecanoate

186020-66-6

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