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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Product Name
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
CAS No.
186020-66-6
Chemical Name
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonyms
HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
CBNumber
CB1497771
Molecular Formula
C13H26O6
Formula Weight
278.34
MOL File
186020-66-6.mol
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property

Boiling point:
365.8±27.0 °C(Predicted)
Density 
1.052 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.446
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
clear liquid
pka
14.36±0.10(Predicted)
color 
Colorless to Light yellow to Light orange
BRN 
7638988
CAS DataBase Reference
186020-66-6
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Safety

WGK Germany 
3
10
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
83062
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity
≥97.0%(GC)
Packaging
5G
Price
$138.8
Updated
2024/03/01
Sigma-Aldrich
Product number
83062
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity
≥97.0%(GC)
Packaging
1g
Price
$78.2
Updated
2023/06/20
TCI Chemical
Product number
B5587
Product name
tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity
>97.0%(GC)
Packaging
1g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
B5587
Product name
tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity
>97.0%(GC)
Packaging
5g
Price
$272
Updated
2024/03/01
TRC
Product number
B809908
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Packaging
100mg
Price
$60
Updated
2021/12/16
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Alkyl/ether

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Suppliers

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
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caoy@chemextension.com
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China
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4755
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Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd
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+86-021-50929289 86186163093
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sales@ypptech.com.cn
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China
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Hebei led the biological technology co., LTD
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18032827359
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2922659299@qq.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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+86-21-50462321
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ChemPep, Inc.
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+1 (888) 615-9178 / (561) 791-8787
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+1 (561) 791-8728
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United States
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ZhengZhou HuaWen Chemical Co.Ltd
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0370-2785118 17550508557
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QQ:3470079902
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675141927@qq.com
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China
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Chengdu Pukang Biotechnology Co., Ltd
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028-82550498 19102685862
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086-28-82550468
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sales@pu-kang.com
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China
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T&W GROUP
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021-61551611 13296011611
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+86 21-50676805
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contact@trustwe.com
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View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Hydroxy-PEG3-t-butyl ester 186020-66-6
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-25
Career Henan Chemical Co
Product
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- 186020-66-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

186020-66-6, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Related Search:


  • HO-PEG3-COOtBu
  • Hydroxy-PEG3-(CH2)2-Boc
  • OH-PEG3-CH2CH2COOtBu
  • OH-PEG3-TBA
  • HO-PEG3-t-Butyl ester
  • tert-Butyl 3-(2-(2-(2-hydroxyethoxy)
  • 12-HYDROXY-4 7 10-TRIOXA-
  • Hydroxy-PEG4-t-butyles
  • TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
  • HO-PEG3-tBu
  • HO-PEG3-CH2CH2COOtBu
  • 3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
  • tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)
  • Hydroxy-PEG4-t-butylester
  • Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • HO(CH2CH2O)3CH2CH2COOT-BU
  • tert-Butyl PEG3 propanoate
  • 12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester
  • HO-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • OH-PEG3-(CH2)2-Boc
  • 186020-66-6
  • peg