FMoc-NH-8(ethylene glycol)-acetic acid

Product Name: FMoc-NH-8(ethylene glycol)-acetic acid
CAS No.: 868594-52-9
Chemical Name: FMoc-NH-8(ethylene glycol)-acetic acid
Synonyms: FMoc-NH-PEG8-CH2COOH;Fmoc-NH-PEG8-CH2CO2H;Fmoc-PEG8-acetic acid;Fmoc-N-Amido-PEG8-CH2COOH;Fmoc-N-amido-PEG8-acetic acid;Fmoc-NH-8(ethylene glycol)-actic acid;FMoc-NH-8(ethylene glycol)-acetic acid;FMoc-NH-8(ethylene glycol)-acetic acid ISO 9001：2015 REACH;26-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid;5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
CBNumber: CB72546851
Molecular Formula: C33H47NO12
Formula Weight: 649.73
MOL File: 868594-52-9.mol

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FMoc-NH-8(ethylene glycol)-acetic acid Property

Boiling point:: 773.7±60.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
solubility: DMSO : 100 mg/mL (153.91 mM; Need ultrasonic)
form: Oil
pka: 3.39±0.10(Predicted)
color: Light yellow to brown

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22048
Product name: Fmoc-NH-PEG8-CH2COOH
Purity: 98%
Packaging: 500mg
Price: $380
Updated: 2021/12/16

BroadPharm

Product number: BP-22048
Product name: Fmoc-NH-PEG8-CH2COOH
Purity: 98%
Packaging: 1g
Price: $560
Updated: 2021/12/16

Activate Scientific

Product number: AS104016
Product name: FmocNH-PEG8-CH2COOH
Purity: 95+%
Packaging: 1g
Price: $583
Updated: 2021/12/16

chempep

Product number: 280105
Product name: Fmoc-NH-PEG8-CH2COOH
Purity: >=95%
Packaging: 5g
Price: $1205
Updated: 2021/12/16

BroadPharm

Product number: BP-22048
Product name: Fmoc-NH-PEG8-CH2COOH
Purity: 98%
Packaging: 5G
Price: $1450
Updated: 2021/12/16

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FMoc-NH-8(ethylene glycol)-acetic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG8-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.

FMoc-NH-8(ethylene glycol)-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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FMoc-NH-8(ethylene glycol)-acetic acid Suppliers

China 74 India 1 Japan 1 United Kingdom 1 United States 11 Global 88

Borenpharm Co., Ltd

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868594-52-9, FMoc-NH-8(ethylene glycol)-acetic acidRelated Search:

HS-PEG4-tBu HEXAETHYLENE GLYCOL MONOMETHYL ETHER H2N-PEG8-tBu 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester Amino-PEG4-acid 2,5,8,11,14,17,20-Heptaoxadocosane-22-thiol Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Fmoc-N-amido-PEG11-acid Fmoc-N-amido-PEG17-acid Fmoc-NH-PEG2-CH2CO2H FMoc-NH-5(ethylene glycol)-acetic acid Fmoc-NH-PEG3-CH2COOH Fmoc-N-amido-PEG15-acid 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Fmoc-N-amido-PEG14-acid FMoc-NH-PEG9-CH2CH2COOH

FMoc-NH-8(ethylene glycol)-acetic acid

FMoc-NH-PEG8-CH2COOH

5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-PEG8-CH2CO2H

Fmoc-PEG8-acetic acid

Fmoc-NH-8(ethylene glycol)-actic acid

FMoc-NH-8(ethylene glycol)-acetic acid ISO 9001：2015 REACH

26-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid

26-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18,21,24-octaoxahexaeicosanoic acid

Fmoc-N-Amido-PEG8-CH2COOH

FmocNH-PEG8-CH2COOH/5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester

2-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Fmoc-N-amido-PEG8-acetic acid

868594-52-9

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