Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
- Product Name
- Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 127828-22-2
- Chemical Name
- Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- N-Boc-2-(2-Aminoethoxy)ethanamine;N-Boc-2-(2-amino-ethoxy)-ethylamine;BOC-NH-PEG1-NH2;NBoc-PEG1-Amine;Amino-PEG2-NH-Boc;Amino-PEGI-NH-Boc;BOC-N-AMIDO-PEG1-NH2;BocNH-PEG?-CH?CH?NH?;Boc-N-amido-PEG1-Amine;t-Boc-Amido-PEG2-Amine
- CBNumber
- CB71054537
- Molecular Formula
- C9H20N2O3
- Formula Weight
- 204.27
- MOL File
- 127828-22-2.mol
Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Property
- Boiling point:
- 321.1±22.0 °C(Predicted)
- Density
- 1.023±0.06 g/cm3(Predicted)
- refractive index
- 1.4560 to 1.4600
- storage temp.
- 2-8°C(protect from light)
- form
- clear liquid
- pka
- 12.24±0.46(Predicted)
- color
- Colorless to Light orange to Yellow
- InChI
- InChI=1S/C9H20N2O3/c1-9(2,3)14-8(12)11-5-7-13-6-4-10/h4-7,10H2,1-3H3,(H,11,12)
- InChIKey
- VULKFBHOEKTQSF-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCN
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B5683
- Product name
- N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 200mg
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B5683
- Product name
- N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- B812603
- Product name
- tert-Butyl(2-(2-aminoethoxy)ethyl)carbamate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB72998
- Product name
- BocNH-PEG1-CH2CH2NH2
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR61058
- Product name
- tert-Butyl[2-(2-aminoethoxy)ethyl]carbamate
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Description
t-Boc-N-Amido-PEG1-amine is a small molecule PEG reagent containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
Colorless viscous liquid
Uses
Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Synthesis
176220-30-7
127828-22-2
Step 4: Synthesis of tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58) Under argon protection, tert-butyl (2-(2-azidoethoxy)ethyl)carbamate (57, 5.0 g, 0.0217 mol) was dissolved in methanol (100 mL) and palladium/carbon catalyst (2.5 g, 10 mL) was added. The reaction mixture was stirred overnight at room temperature under hydrogen (50 psi) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58, 3.0 g). The resulting product can be used directly in the subsequent reaction without further purification. 1H NMR (400 MHz, MeOD) δ 3.48-3.45 (m, 4H), 3.23-3.20 (t, 2H), 2.77-2.75 (m, 2H), 1.43 (s, 9H).
IC 50
PEGs; Alkyl/ether
References
[1] Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841. DOI:10.1021/acs.orglett.9b01326
Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) manufacturers
- Product
- BocNH-PEG1-CH2CH2NH2 127828-22-2
- Price
- US $9310.00/kg
- Min. Order
- 0.5kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2025-11-15
- Product
- Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) 127828-22-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) 127828-22-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08