ChemicalBook > CAS DataBase List > Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Product Name: Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.: 127828-22-2
Chemical Name: Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
Synonyms: N-Boc-2-(2-Aminoethoxy)ethanamine;N-Boc-2-(2-amino-ethoxy)-ethylamine;BOC-NH-PEG1-NH2;NBoc-PEG1-Amine;Amino-PEG2-NH-Boc;Amino-PEGI-NH-Boc;BOC-N-AMIDO-PEG1-NH2;BocNH-PEG?-CH?CH?NH?;Boc-N-amido-PEG1-Amine;t-Boc-Amido-PEG2-Amine
CBNumber: CB71054537
Molecular Formula: C9H20N2O3
Formula Weight: 204.27
MOL File: 127828-22-2.mol

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Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Property

Boiling point:: 321.1±22.0 °C(Predicted)
Density: 1.023±0.06 g/cm3(Predicted)
refractive index: 1.4560 to 1.4600
storage temp.: 2-8°C(protect from light)
form: clear liquid
pka: 12.24±0.46(Predicted)
color: Colorless to Light orange to Yellow
InChI: InChI=1S/C9H20N2O3/c1-9(2,3)14-8(12)11-5-7-13-6-4-10/h4-7,10H2,1-3H3,(H,11,12)
InChIKey: VULKFBHOEKTQSF-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCN

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5683
Product name: N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B5683
Product name: N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $92
Updated: 2025/07/31

TRC

Product number: B812603
Product name: tert-Butyl(2-(2-aminoethoxy)ethyl)carbamate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB72998
Product name: BocNH-PEG1-CH2CH2NH2
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR61058
Product name: tert-Butyl[2-(2-aminoethoxy)ethyl]carbamate
Packaging: 250mg
Price: $70
Updated: 2021/12/16

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Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG1-amine is a small molecule PEG reagent containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Colorless viscous liquid

Uses

Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Synthesis

176220-30-7

127828-22-2

Step 4: Synthesis of tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58) Under argon protection, tert-butyl (2-(2-azidoethoxy)ethyl)carbamate (57, 5.0 g, 0.0217 mol) was dissolved in methanol (100 mL) and palladium/carbon catalyst (2.5 g, 10 mL) was added. The reaction mixture was stirred overnight at room temperature under hydrogen (50 psi) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford tert-butyl [2-(2-aminoethoxy)ethyl]carbamate (58, 3.0 g). The resulting product can be used directly in the subsequent reaction without further purification. 1H NMR (400 MHz, MeOD) δ 3.48-3.45 (m, 4H), 3.23-3.20 (t, 2H), 2.77-2.75 (m, 2H), 1.43 (s, 9H).

IC 50

PEGs; Alkyl/ether

References

[1] Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841. DOI:10.1021/acs.orglett.9b01326

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) manufacturers

LAURENT

Product: BocNH-PEG1-CH2CH2NH2 127828-22-2
Price: US $9310.00/kg
Min. Order: 0.5kg
Purity: 98%
Supply Ability: 200kg
Release date: 2025-11-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) 127828-22-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) 127828-22-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

127828-22-2, Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)Related Search:

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Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

CarbaMic acid, [2-(2-aMinoethoxy)ethyl]-, 1,1-diMethylethyl ester

3-Oxapentane-1,5-diamine, N-BOC protected, 2-(2-Aminoethoxy)ethylamine, N-BOC protected

tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate

N-Boc-2-(2-Aminoethoxy)ethanamine

N-Boc-2-aminoethyl 2-aminoethyl ether

BocNH-PEG1-CH2CH2NH2

N-Boc-2-(2-amino-ethoxy)-ethylamine

t-Boc-N-amido-PEG1-Amine

N-Boc-2-(2-aminoethoxy)ethylamine≥ 98% (GC)

tert-butyl N-[2-(2-aminoethoxy)ethyl]carbamate

BOC-N-AMIDO-PEG1-NH2

BOC-NH-PEG1-NH2

N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine

[2-(2-aMinoethoxy)ethyl]-, 1,1-diMethylethyl ester

Boc-N-amido-PEG1-Amine

Boc-NH-PEG2 Tert-butyl 2-(2-aminoethoxy)ethylcarbamate

[2-(2-Aminoethoxy)ethyl]carbamic Acid tert-Butyl Ester

Amino-PEG2-NH-Boc

Carbamic acid, N-[2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) USP/EP/BP

[2-(2-aminoethoxy)ethyl]-

BocNH-PEG?-CH?CH?NH?

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ...

N-Boc-2-(2-amino-ethoxy)-ethyla

NBoc-PEG1-Amine

t-Boc-Amido-PEG2-Amine

N-[2-(2-Aminoethoxy)ethyl]carbamic acid tert-butyl ester

Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethyl

Amino-PEGI-NH-Boc

127828-22-2

N-BOC

peg