ChemicalBook > CAS DataBase List > TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Product Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
CAS No.: 186020-66-6
Chemical Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonyms: HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
CBNumber: CB1497771
Molecular Formula: C13H26O6
Formula Weight: 278.34
MOL File: 186020-66-6.mol

Less

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property

Boiling point:: 365.8±27.0 °C(Predicted)
Density: 1.052 g/mL at 20 °C (lit.)
refractive index: n20/D 1.446
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: clear liquid
pka: 14.36±0.10(Predicted)
color: Colorless to Light yellow to Light orange
BRN: 7638988
InChI: InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
InChIKey: KSXVEOLRERRELV-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCO
CAS DataBase Reference: 186020-66-6

Less

Safety

WGK Germany: 3
F: 10
HS Code: 2918999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 5G
Price: $298
Updated: 2025/07/31

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 1g
Price: $78.2
Updated: 2023/06/20

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 1g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 5g
Price: $272
Updated: 2025/07/31

TRC

Product number: B809908
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Less

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

Synthesis

1663-39-4

112-27-6

186020-66-6

Synthesis of Compound 71; Step a: Sodium metal (0.10 g, 4.35 mmol) was slowly added to an anhydrous tetrahydrofuran (250 mL) solution of triethylene glycol (64.0 mL, 0.48 mol) at room temperature. After the sodium was completely dissolved, tert-butyl acrylate (24.0 mL, 0.164 mol) was added dropwise to the system. The reaction mixture was stirred continuously at room temperature for 20 h. The reaction was subsequently neutralized with 1.0 N hydrochloric acid solution (4 mL). After removal of the solvent by distillation under reduced pressure, the residue was suspended in saturated aqueous sodium chloride solution and extracted with ethyl acetate (3 x 70 mL). The organic phases were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. After concentration under reduced pressure to remove the solvent, the tert-butyl acrylate adduct (40.23 g, 0.157 mol, 96% yield) was obtained as a colorless oil, which could be used for subsequent reactions without further purification. The product was analyzed by high performance liquid chromatography (HPLC): retention time t R = 10.2 min.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

< span>

PEGs

Alkyl/ether

References

[1] Patent: US2006/228325, 2006, A1. Location in patent: Page/Page column 63
[2] Patent: CN105524053, 2016, A. Location in patent: Paragraph 0468; 0469; 0470
[3] Journal of Organic Chemistry, 1997, vol. 62, # 4, p. 813 - 826
[4] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
[5] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 295

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials

Raw materials

Preparation Products

Less

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Suppliers

Americas 1 China 135 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 19 Global 161

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: ET-market@chemextension.com
Country: China
ProdList: 4671
Advantage: 58

Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 021-50929289 18616309303
Fax: -
Email: sales@ypptech.com.cn
Country: China
ProdList: 287
Advantage: 58

Hebei led the biological technology co., LTD

Tel: 0311-89629263; 18032827359
Email: 2922659299@qq.com
Country: China
ProdList: 65
Advantage: 58

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 497
Advantage: 58

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

Nanjing Junnahe Biopharmaceutical Co., Ltd

Tel: 025-58367986 17351780683
Fax: QQ3209878052
Email: amy.xiang@ally-chem.com
Country: China
ProdList: 354
Advantage: 60

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Shanghai Boka-chem Tech. Inc.

Tel: 400-026-1533/(021) 6478-0600
Fax: +86 (21) 6459-2060
Email: sales@bokachem.com
Country: China
ProdList: 876
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9986
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
ProdList: 1245
Advantage: 55

Shanghai Synchem Technology Co., Ltd.

Tel: 021-64502386 18017349250
Email: shsynchem@gmail.com
Country: China
ProdList: 296
Advantage: 60

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4992
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8595
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Hangzhou HanLai Biochemical Technology Co., Ltd.

Tel: 571-86101219 18768477782
Fax: -
Email: sales09@leobiochem.com
Country: China
ProdList: 433
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9722
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Henan Aosman Biotechnology Co., LTD

Tel: 0371-0371-61318675 17719817155
Fax: 0371-61318675
Email: sales@xlinebio.com
Country: China
ProdList: 2857
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Shanghai Chenghe Medical Technology Co. Ltd.

Tel: 021-021-54382182 18601603956
Email: 18601603956@163.com
Country: China
ProdList: 1255
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Less

View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers

LAURENT

Product: HO-PEG3-CH2CH2COOtBu 186020-66-6
Price: US $7315.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

LAURENT

Product: HO-PEG3-CH2CH2COOtBu 186020-66-6
Price: US $7315.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Hydroxy-PEG3-(CH2)2-Boc 186020-66-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

186020-66-6, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Related Search:

Hydroxy-PEG4-t-butyl ester Bis-PEG6-t-butyl ester tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate alpha-Azido-omega-hydroxy octa(ethylene glycol) PENTAETHYLENE GLYCOL (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide alpha, oMega-Dipropionic acid hexaethylene glycol Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid FMoc-NH-8(ethylene glycol)-acetic acid FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID HEPTAETHYLENE GLYCOL MPEG7-CH2CH2COOH Amino-PEG2-acid 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL Propargyl-PEG5-alcohol Triethylene Glycol Mono(2-propynyl) Ether Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) Hydroxy-PEG3-ethyl ester

HO-PEG3-COOtBu

Hydroxy-PEG3-(CH2)2-Boc

OH-PEG3-CH2CH2COOtBu

OH-PEG3-TBA

HO-PEG3-t-Butyl ester

tert-Butyl 3-(2-(2-(2-hydroxyethoxy)

12-HYDROXY-4 7 10-TRIOXA-

Hydroxy-PEG4-t-butyles

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

HO-PEG3-tBu

HO-PEG3-CH2CH2COOtBu

3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester

tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)

Hydroxy-PEG4-t-butylester

Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

HO(CH2CH2O)3CH2CH2COOT-BU

tert-Butyl PEG3 propanoate

12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester

HO-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

OH-PEG3-(CH2)2-Boc

Hydroxy-PEG3-(CH2)2-Boc97

<i>tert</i>-Butyl 12-hydroxy-4,7,10-trioxadodecanoate

186020-66-6

peg