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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Product Name
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
CAS No.
186020-66-6
Chemical Name
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonyms
HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
CBNumber
CB1497771
Molecular Formula
C13H26O6
Formula Weight
278.34
MOL File
186020-66-6.mol
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property

Boiling point:
365.8±27.0 °C(Predicted)
Density 
1.052 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.446
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
clear liquid
pka
14.36±0.10(Predicted)
color 
Colorless to Light yellow to Light orange
BRN 
7638988
CAS DataBase Reference
186020-66-6
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Safety

WGK Germany 
3
F 
10
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
83062
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity
≥97.0%(GC)
Packaging
5G
Price
$138.8
Updated
2024/03/01
Sigma-Aldrich
Product number
83062
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity
≥97.0%(GC)
Packaging
1g
Price
$78.2
Updated
2023/06/20
TCI Chemical
Product number
B5587
Product name
tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity
>97.0%(GC)
Packaging
1g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
B5587
Product name
tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity
>97.0%(GC)
Packaging
5g
Price
$272
Updated
2024/03/01
TRC
Product number
B809908
Product name
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Packaging
100mg
Price
$60
Updated
2021/12/16
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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Alkyl/ether

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Suppliers

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View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Hydroxy-PEG3-t-butyl ester 186020-66-6
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-25
Career Henan Chemical Co
Product
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- 186020-66-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

186020-66-6, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Related Search:

Hydroxy-PEG4-t-butyl ester Bis-PEG6-t-butyl ester tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate alpha-Azido-omega-hydroxy octa(ethylene glycol) PENTAETHYLENE GLYCOL (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide alpha, oMega-Dipropionic acid hexaethylene glycol Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid FMoc-NH-8(ethylene glycol)-acetic acid FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID HEPTAETHYLENE GLYCOL MPEG7-CH2CH2COOH Amino-PEG2-acid 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL Propargyl-PEG5-alcohol Triethylene Glycol Mono(2-propynyl) Ether Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) HEPTAETHYLENE GLYCOL Monobenzyl ether

  • HO-PEG3-COOtBu
  • Hydroxy-PEG3-(CH2)2-Boc
  • OH-PEG3-CH2CH2COOtBu
  • OH-PEG3-TBA
  • HO-PEG3-t-Butyl ester
  • tert-Butyl 3-(2-(2-(2-hydroxyethoxy)
  • 12-HYDROXY-4 7 10-TRIOXA-
  • Hydroxy-PEG4-t-butyles
  • TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
  • HO-PEG3-tBu
  • HO-PEG3-CH2CH2COOtBu
  • 3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
  • tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)
  • Hydroxy-PEG4-t-butylester
  • Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • HO(CH2CH2O)3CH2CH2COOT-BU
  • tert-Butyl PEG3 propanoate
  • 12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester
  • HO-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • OH-PEG3-(CH2)2-Boc
  • 186020-66-6
  • peg