Hydroxy-PEG3-t-butylester Chemical Properties

Boiling point:

321.8±22.0 °C(Predicted)

Density 

1.046±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO

form 

clear liquid

pka

14.36±0.10(Predicted)

color 

Colorless to Almost colorless

Safety Information

HS Code 

2918999090

Hydroxy-PEG3-t-butylester Usage And Synthesis

Description

Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Hydroxy-PEG3-t-butylester(133803-81-3)Related Product Information

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