PEG7-t-butly ester Chemical Properties

Boiling point:

481.8±40.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

refractive index 

n/D 1.454

storage temp. 

-20°C

pka

14.36±0.10(Predicted)

form 

viscous liquid

color 

Colourless

InChI

InChI=1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3

InChIKey

VGGDPFAYSOSIOK-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCO

Safety Information

HS Code 

2942000090

PEG7-t-butly ester Usage And Synthesis

Description

Hydroxy-PEG6-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

reaction suitability

reagent type: cross-linking reagent

IC 50

PEGs; Alkyl/ether

PEG7-t-butly ester(361189-64-2)Related Product Information

• HO-PEG12-tBu
• tert-Butyl 3-(2-hydroxyethoxy)propanoate
• PEG5-(CH2CO2H)2
• Bis-PEG6-t-butyl ester
• tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate
• Hydroxy-PEG3-ethyl ester
• 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid
• PEG4-acid
• HO-PEG6-CH2CH2COOH
• α,ω-dipropionic acid tetraethylene glycol
• Bis-PEG6-acid
• alpha-[3-(1,1-Dimethylethoxy)-3-oxopropyl]-omega-hydroxypoly(oxy-1,2-ethanediyl)
• HO-PEG8-CH2CH2COOH
• Hydroxy-PEG5-acid
• PEG5-acid
• PEG9-t-butly ester
• HO-PEG10-tBu
• Hydroxy-PEG3-t-butylester