PEG7-t-butly ester Chemical Properties

Boiling point:

481.8±40.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

storage temp. 

-20°C

pka

14.36±0.10(Predicted)

form 

viscous liquid

color 

Colourless

Safety Information

HS Code 

2942000090

PEG7-t-butly ester Usage And Synthesis

Description

Hydroxy-PEG6-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

PEG7-t-butly ester(361189-64-2)Related Product Information

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• Bis-PEG6-t-butyl ester
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• HO-PEG8-CH2CH2COOH
• Hydroxy-PEG5-acid
• PEG5-acid
• PEG9-t-butly ester
• HO-PEG10-tBu
• Hydroxy-PEG3-t-butylester